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Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress

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作者：
Feng Lianyuan[1] * ; Sharma Aruna[2] ; Wang Zhenguo[3] ; Muresanu Dafin F[4,5] ; Tian Z Ryan[6] ; José Vicente Lafuente Vicente[7] ; Buzoianu Anca D[8] ; Nozari Ala[9] ; Li Cong[10] ; Zhang Ziquiang[10] ; Lin Chen[11] ; Huang Hongyun[12] ; Manzhulo Igor[13] ; Wiklund Lars[2] ; Sharma Hari Shanker[2] ;
机构： [1]Department of Neurology, Bethune International Peace Hospital, Zhongshan Road (West), Shijiazhuang, Hebei Province, P.R. China [2]International Experimental Central Nervous System Injury & Repair (IECNSIR), Dept. of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden [3]Shijiazhuang Pharma Group NBP Pharmaceutical Co. Ltd., Economic and Technological Development Zone, Shijiazhuang City, Hebei Province, P.R. China [4]Dept. Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania [5]“RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania [6]Dept. Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States [7]LaNCE, Dept. Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain [8]Department of Clinical Pharmacology and Toxicology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania [9]Department of Anesthesiology, Boston University, Albany str, Boston, MA, United States [10]Department of Neurosurgery, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, Guangdong, P.R. China [11]Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, P.R. China [12]Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China [13]Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia
出处：
DOI： 10.1016/bs.irn.2023.06.005
ISSN：

摘要：
Stress is one of the most serious consequences of life leading to several chronic diseases and neurodegeneration. Recent studies show that emotional stress and other kinds of anxiety and depression adversely affects Parkinson's disease symptoms. However, the details of how stress affects Parkinson's disease is still not well known. Traumatic brain injury, stroke, diabetes, post-traumatic stress disorders are well known to modify the disease precipitation, progression and persistence. However, show stress could influence Parkinson's disease is still not well known. The present investigation we examine the role of immobilization stress influencing Parkinson's disease brain pathology in model experiments. In ore previous report we found that mild traumatic brain injury exacerbate Parkinson's disease brain pathology and nanodelivery of dl-3-n-butylphthalide either alone or together with mesenchymal stem cells significantly attenuated Parkinson's disease brain pathology. In this chapter we discuss the role of stress in exacerbating Parkinson's disease pathology and nanowired delivery of dl-3-n-butylphthalide together with monoclonal antibodies to alpha synuclein (ASNC) is able to induce significant neuroprotection. The possible mechanisms of dl-3-n-butylphthalide and ASNC induced neuroprotection and suitable clinical therapeutic strategy is discussed.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 神经科学
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第一作者：
第一作者机构： [1]Department of Neurology, Bethune International Peace Hospital, Zhongshan Road (West), Shijiazhuang, Hebei Province, P.R. China
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推荐引用方式(GB/T 7714)：
Feng Lianyuan,Sharma Aruna,Wang Zhenguo,et al.Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress[J].NANOWIRED DELIVERY OF DRUGS AND ANTIBODIES FOR NEUROPROTECTION IN BRAIN DISEASES WITH CO-MORBIDITY FACTORS.2023,171:47-82.doi:10.1016/bs.irn.2023.06.005.
APA：
Feng Lianyuan,Sharma Aruna,Wang Zhenguo,Muresanu Dafin F,Tian Z Ryan...&Sharma Hari Shanker.(2023).Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress.NANOWIRED DELIVERY OF DRUGS AND ANTIBODIES FOR NEUROPROTECTION IN BRAIN DISEASES WITH CO-MORBIDITY FACTORS,171,
MLA：
Feng Lianyuan,et al."Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress".NANOWIRED DELIVERY OF DRUGS AND ANTIBODIES FOR NEUROPROTECTION IN BRAIN DISEASES WITH CO-MORBIDITY FACTORS 171.(2023):47-82

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