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Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis

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资源类型：
Pubmed体系：
作者：
Tian Run[1,2] * ; Zhang Yu-Zhuo[3] * ; Cheng Xianbo[4] * ; Xu Baojun[5] ; Wu Haitao[6] ; Liang Zhi-Qun[7] ; Rahman Muyassar[8] ; Wang Yong[1] ; Zeng Nian-Kai[1,2] ;
机构： [1]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China [2]Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou 571158, China [3]Gongyi Public Traditional Chinese Medicine Hospital, Henan Province, Zhengzhou 451200, China [4]Dietary Fiber Isolation and Structural Characterization Laboratory, Guangxi Vocational College of Technology and Business, Nanning 530003, China [5]Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, China [6]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China [7]College of Science, Hainan University, Haikou 570228, China [8]General Hospital of the Third Division of Xinjiang Production and Construction Corps, Kashgar Hospital District, Kashgar 844000, China
出处：
DOI： 10.1016/j.ijbiomac.2023.127200
ISSN：

关键词： Hypoglycemic effect Structure elucidation Physicochemical properties

摘要：
A polysaccharide CY-2 from C. yunnanensis was obtained through a process of consecutive water extraction, alcohol precipitation, and DEAE-52 fast-flow chromatography. CY-2, with an average molecular weight of 2.69 × 104 Da mainly consisted of glucose and mannose with a molar ratio of 33.5: 56.9. Infrared spectrum (IR), methylation analysis, and nuclear magnetic resonance (NMR) results revealed that CY-2 may have a backbone consisting of →6)-α-D-Manp-(1 → 3)-β-D-Glcp-(1→, and branch chain β-D-Glcp-(1→. Meanwhile, CY-2 had a higher inhibition rate on α-glucosidase activity compared with other fractions (CY-0, CY-1, and CY-4) and was a mixed competitive inhibitor. In addition, CY-2 at the concentration of 10 μg/mL presented a superior power to improve glucose consumption and metabolism in HepG2 cells compared with metformin. Overall, these findings highlight the potential value of CY-2 as a hypoglycemic agent.Copyright © 2023. Published by Elsevier B.V.

基金：
This study was supported by the National Natural Science Foundation of China (No. 32160001).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 高分子科学 2 区 应用化学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [1]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China [2]Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou 571158, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China [2]Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou 571158, China
推荐引用方式(GB/T 7714)：
Tian Run,Zhang Yu-Zhuo,Cheng Xianbo,et al.Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis[J].International journal of biological macromolecules.2023,127200.doi:10.1016/j.ijbiomac.2023.127200.
APA：
Tian Run,Zhang Yu-Zhuo,Cheng Xianbo,Xu Baojun,Wu Haitao...&Zeng Nian-Kai.(2023).Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis.International journal of biological macromolecules,,
MLA：
Tian Run,et al."Structural characterization, and in vitro hypoglycemic activity of a polysaccharide from the mushroom Cantharellus yunnanensis".International journal of biological macromolecules .(2023):127200

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