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Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics

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收录情况： ◇ SCIE

作者：
Qin Pengfei[2,6] * ; Chen Huaxian[1,3,4] * ; Wang Yuhang[2,5] * ; Huang Liang[1,3,4] * ; Huang Ke[2] * ; Xiao Guozhong[1,3,4] ; Han Changpeng[8] ; Hu Jiancong[3,4,9] ; Lin Dezheng[3,4,9] ; Wan Xingyang[1,3,4] ; Zheng Yihui[1,3,4] ; Liu Yufeng[10] ; Li Guiming[1,3,4] ; Yang Haojie[8] ; Ye Shubiao[1,3,4] ; Luo Minyi[1,3,4] ; Fu Yuanji[1,3,4] ; Xu Hao[11] ; Wen Luping[12] ; Guo Zhiwei[13] ; Shen Xunan[14] ; Li Zeyu[2,15] ; Wang Chunqing[2,15] ; Chen Xi[2] ; Wang Linying[2] ; Sun Liuyong[2] ; Ren Donglin[1,3,4] ; Wu Liang[2,6] ; Wang Jufang[5] ; Liu Shiping[2,7] ; Lin Hongcheng[1,3,4] ;
机构： [1]Department of Coloproctology, Department of General Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China [2]BGI Research, Shenzhen 518083, China [3]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China [4]Guangdong Institute of Gastroenterology, Guangzhou 510655, China [5]School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China [6]BGI Research, Chongqing 401329, China [7]BGI Research, Hangzhou 310030, China [8]Department of Coloproctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China [9]Department of Endoscopic Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China [10]Center for Medical Research on Innovation and Translation, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510320, China [11]Department of Coloproctology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China [12]Department of Coloproctology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221005, China [13]Department of Coloproctology, The Eighth Hospital of Wuhan, Wuhan 430000, China [14]BGI Research, Beijing 102601, China [15]College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
出处：
DOI： 10.1016/j.xcrm.2023.101231
ISSN：

摘要：
Neoadjuvant chemotherapy (NAC) for rectal cancer (RC) shows promising clinical response. The modulation of the tumor microenvironment (TME) by NAC and its association with therapeutic response remain unclear. Here, we use single-cell RNA sequencing and spatial transcriptome sequencing to examine the cell dynamics in 29 patients with RC, who are sampled pairwise before and after treatment. We construct a high-resolution cellular dynamic landscape remodeled by NAC and their associations with therapeutic response. NAC markedly reshapes the populations of cancer-associated fibroblasts (CAFs), which is strongly associated with therapeutic response. The remodeled CAF subsets regulate the TME through spatial recruitment and crosstalk to activate immunity and suppress tumor progression through multiple cytokines, including CXCL12, SLIT2, and DCN. In contrast, the epithelial-mesenchymal transition of malignant cells is upregulated by CAF_FAP through MIR4435-2HG induction, resulting in worse outcomes. Our study demonstrates that NAC inhibits tumor progression and modulates the TME by remodeling CAFs.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
This study was supported by fundings from the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (no. 2022B1515020003); the National Natural Science Foundation of China (nos. 82174369 and 81973847); the Natural Science Foundation of Guangdong Province (no. 2020A1515011254); the Guangzhou Clinical High-Tech Project (no. 2023P-GX09); the Bethune Charitable Foundation (no. zllcaxw-14); the Open Project of BGI-Shenzhen, Shenzhen 518000, China (no. BGIRSZ20210005); the National Key Research and Development Program of China (nos. 2021YFA0805100 and 2021YFC2501900); and the Guangdong Basic and Applied Basic Research Foundation (no. 2021A1515110832).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [2]BGI Research, Shenzhen 518083, China [6]BGI Research, Chongqing 401329, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Coloproctology, Department of General Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China [2]BGI Research, Shenzhen 518083, China [3]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China [4]Guangdong Institute of Gastroenterology, Guangzhou 510655, China [6]BGI Research, Chongqing 401329, China [7]BGI Research, Hangzhou 310030, China
推荐引用方式(GB/T 7714)：
Qin Pengfei,Chen Huaxian,Wang Yuhang,et al.Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics[J].CELL REPORTS MEDICINE.2023,4(10):101231.doi:10.1016/j.xcrm.2023.101231.
APA：
Qin Pengfei,Chen Huaxian,Wang Yuhang,Huang Liang,Huang Ke...&Lin Hongcheng.(2023).Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics.CELL REPORTS MEDICINE,4,(10)
MLA：
Qin Pengfei,et al."Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics".CELL REPORTS MEDICINE 4..10(2023):101231

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