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Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liang Xisong[1,2] * ; Wang Zeyu[1,2] * ; Dai Ziyu[1,2] ; Liu Jian[3] ; Zhang Hao[1,2] ; Wen Jie[1,2] ; Zhang Nan[4] ; Zhang Jian[5] ; Luo Peng[5] ; Liu Zaoqu[6] ; Liu Zhixiong[1,2,*1] ; Cheng Quan[1,2,7,*1] ;
机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [3]Experiment Center of Medical Innovation, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan, China [4]College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, PR China [5]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China [6]Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China [7]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China
出处：
DOI： 10.1016/j.clim.2023.109802
ISSN：

关键词： Oxidative stress Glioblastoma SOD3 Microglia Macrophage

摘要：
Oxidative stress dually affected cancer progression, while its effect on glioblastomas remained unclear. Herein, we clustered the multicenter glioblastoma cohorts based on the oxidative-stress-responsive genes (OSS) expression. We found that cluster 2 with high OSS levels suffered a worse prognosis. Functional analyses and immune-related analyses results exhibited that M2-like pro-tumoral macrophages and neutrophils were enriched in cluster 2, while Natural killer cells' infiltration was decreased. The increased M2-like pro-tumoral macrophages in cluster 2 was confirmed by immunofluorescence. An integrated single-cell analysis validated the malignant features of cluster 2 neoplastic cells and discovered their crosstalk with M2-like pro-tumoral macrophages. Moreover, we observed that SOD3 knockdown increased the M1-like anti-tumoral transformation and decreased the M2-like pro-tumoral transformation of macrophage in vitro and in vivo. Comprehensively, we revealed oxidative stress' prognostic and immunosuppressive potential in glioblastoma and confirmed SOD3's role in regulating macrophage M2-like pro-tumoral transformation, providing novel targets for developing TME-targeted strategies.Copyright © 2023. Published by Elsevier Inc.

基金：
This work was supported by the Hunan Provincial Natural Science Foundation of China [NO. 2022JJ20095]; the National Natural Science Foundation of China [NO. 82073893, NO. 82172685]; the Hunan Provincial Health Committee Foundation of China [NO. 202204044869].
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2022]版：
Q1 IMMUNOLOGY
最新[2023]版：
Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [7]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China [*1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, PR China.
推荐引用方式(GB/T 7714)：
Liang Xisong,Wang Zeyu,Dai Ziyu,et al.Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma[J].CLINICAL IMMUNOLOGY.2024,258:109802.doi:10.1016/j.clim.2023.109802.
APA：
Liang Xisong,Wang Zeyu,Dai Ziyu,Liu Jian,Zhang Hao...&Cheng Quan.(2024).Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma.CLINICAL IMMUNOLOGY,258,
MLA：
Liang Xisong,et al."Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma".CLINICAL IMMUNOLOGY 258.(2024):109802

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