机构：[1]Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China.[2]Guangdong Key Lab of Medical Electronic Instruments and Polymer Material Products, Guangzhou 510500, China.[3]National Engineering Research Center for Healthcare Devices, Guangzhou 510500, China.[4]Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangzhou 510515, Guangdong Province, China.[5]Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan 528031, Guangdong Province, China.
Chronic wound infection often leads to irregular tissue closure and accompanies delayed healing and economy issues. Developing an ideal wound dressing that can control the occurrence of antibacterial infections and biological responses is highly desirable. In this study, a multifunctional hybrid hydrogel (GS@EG-Cu-CA NPs) containing synthesized thiolated gelatin, methacrylated silk fibroin, and (-)-epigallocatechin gallate-copper ionic-carrageenan nanoparticles (EG-Cu-CA NPs) was engineered by a thio-ene click reaction. The metal-polyphenol EG-Cu-CA NPs were encapsulated with kappa-carrageenan to enhance its aqueous-soluble, mechanical, and bioactive properties and endowed the hydrogel dressing with fascinating antibacterial, antioxidation, and nitric oxide (NO) generation by catalyzing. The hybrid hydrogels also illustrated a favorable cytocompatibility. Benefiting from the thio-ene click reaction, the hybrid hydrogels were injected and photocured rapidly in situ to cover an irregular wound. In an SD rat full-thickness skin-wound-infected model, the methicillin-resistant Staphylococcus aureus-infected wound covered with GS@EG-Cu-CA NPs was almost completely healed after 10 days. This study presents a facile design of hydrogel dressing incorporating metal-polyphenol nanoparticles, which demonstrates a promising potential way for dealing with effective wound infection management and other complicated wound healings.
基金：
Special Fund Project of the
Guangdong Academy of Sciences to Build First-Class Research
Institutions in China (2021GDASYL-20210103033,
2020GDASYL-20200103039, 2021GDASYL-20210103030),
the GDAS’ Project of Science and Technology Development
(2022GDASZH-2022010110), the National Natural Science
Foundation of China (no. 32201107), Guangdong Research
and Development Plan in Key Areas (2020B1111560001) and
Young Talent Support Project of Guangzhou Association for
Science and Technology (QT-2023-041).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区化学
小类|1 区有机化学1 区高分子科学2 区生化与分子生物学
最新[2025]版：
大类|1 区化学
小类|1 区有机化学1 区高分子科学2 区生化与分子生物学
第一作者：
第一作者机构：[1]Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China.[2]Guangdong Key Lab of Medical Electronic Instruments and Polymer Material Products, Guangzhou 510500, China.[3]National Engineering Research Center for Healthcare Devices, Guangzhou 510500, China.
通讯作者：
通讯机构：[1]Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China.[2]Guangdong Key Lab of Medical Electronic Instruments and Polymer Material Products, Guangzhou 510500, China.[3]National Engineering Research Center for Healthcare Devices, Guangzhou 510500, China.
推荐引用方式(GB/T 7714)：
Zeng Zhiwen,Guo Jiayi,Shen Guangxin,et al.Antibacterial-Antioxidative Thiolated Gelatin/Methacrylated Silk Fibroin Hydrogels with Nitric Oxide Release Catalyzed by Metal-Polyphenol Nanoparticles for MRSA-Infected Wound Healing[J].Biomacromolecules.2023,doi:10.1021/acs.biomac.3c00696.
APA：
Zeng Zhiwen,Guo Jiayi,Shen Guangxin,Guo Cuiping,Pei Dating...&Yu Shan.(2023).Antibacterial-Antioxidative Thiolated Gelatin/Methacrylated Silk Fibroin Hydrogels with Nitric Oxide Release Catalyzed by Metal-Polyphenol Nanoparticles for MRSA-Infected Wound Healing.Biomacromolecules,,
MLA：
Zeng Zhiwen,et al."Antibacterial-Antioxidative Thiolated Gelatin/Methacrylated Silk Fibroin Hydrogels with Nitric Oxide Release Catalyzed by Metal-Polyphenol Nanoparticles for MRSA-Infected Wound Healing".Biomacromolecules .(2023)
化学