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Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Tian Ju[1] * ; Li Xiong Jie[1] * ; Ma Yongshi[2] ; Mai Zhiming[3] ; Yang Yao[4] ; Luo Min[3] ; Xu Wenping[5] ; Chen Kui[2,3] ; Chen Xuri[6] ; Tang Jianbing[7] ; Cheng Biao[8,7] ; Cui Xiao[7,9] ;
机构： [1]Department of Plastic Surgery, People’s Hospital of Zhongshan City, Zhongshan 528421, Guangdong, China [2]College of Life Science and Technology, Jinan University, Guangzhou 510630, Guangdong, China [3]Obstetrics and Gynaecology Department, General Hospital of Southern Theatre Command, PLA, Guangzhou 510010, China [4]Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China [5]Department of General Practice, General Hospital of Southern Theatre Command, PLA, Guangzhou 510010, China [6]Department of General Practice, The Third Afliated Hospital of Guangzhou Medical University, Guangzhou 510150, China [7]Department of Burn and Plastic Surgery, General Hospital of Southern Theatre Command, PLA, Guangzhou 510010, China [8]The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area of Chinese PLA, Guangzhou 510010, China [9]Department of Physiotherapy, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510405, Guangdong, China
出处：
DOI： 10.1038/s41598-023-45747-3
ISSN：

摘要：
Platelet-rich plasma (PRP) has gained significant attention in the field of regenerative medicine due to its potential therapeutic applications. However, few studies have reported the components, especially anti-ageing-related components, of PRP derived from umbilical cord blood (UCB). It is essential to understand the influence of age on the composition and efficacy of PRP to optimize its clinical use. The present study compared the concentrations of bioactive components in PRP from healthy female adults and UCB-derived PRP. PRP was obtained from blood samples from females in four age groups (12 per group): neonates (UCB donors) and adults aged 18-25, 26-45, and 46-65 years, respectively. The concentrations of epidermal growth factor, basic fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1, platelet-derived growth factor-AA (PDGF-AA), PDGF-AB/BB, vascular endothelial growth factor A, RANTES, TIMP-1, TIMP-2, GDF11, and clusterin and activity of superoxide dismutase, catalase, and glutathione peroxidase (GPx) in the PRP samples were determined and compared among groups. Pairwise comparisons between the groups showed statistically significant differences in the concentrations of some bioactive components of PRP, such as FGF-2, PDGF-AB/BB, and clusterin, and GPx activity. UCB-derived PRP contains various active ingredients such as VEGF-A, CAT activity, and TIMP-2. Contrary to expectations, UCB-derived PRP did not show higher concentrations of the anti-ageing protein GDF11. Because UCB is a rich source of bioactive components with low immunogenicity, its use in PRP preparation is an important research direction for future studies.© 2023. The Author(s).

基金：
China Postdoctoral Science Foundation [Grant Number 2017M623430]; the National Natural Science Foundation of China [Grant Numbers 81671924, 81272105]; the National Key Research and Development Plan of China [Grant Number 2017YFC1103301]; the Science and Technology Key Project of Guangdong Province [Grant Number 2014B020212010]; the Military Medical Innovation Special Project [Grant Number 18CXZ029]; the Major Special Project for Collaborative Innovation of Health Care in Guangzhou [Grant Number 158100062]; and the Natural Science Foundation of Guangdong Province [Grant Number 2015A030310113]; the Guangdong Provincial Administration of Traditional Chinese Medicine (20241357).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
最新[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
JCR分区：
出版当年[2021]版：
Q2 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Plastic Surgery, People’s Hospital of Zhongshan City, Zhongshan 528421, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [7]Department of Burn and Plastic Surgery, General Hospital of Southern Theatre Command, PLA, Guangzhou 510010, China [8]The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area of Chinese PLA, Guangzhou 510010, China [9]Department of Physiotherapy, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510405, Guangdong, China
推荐引用方式(GB/T 7714)：
Tian Ju,Li Xiong Jie,Ma Yongshi,et al.Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age[J].SCIENTIFIC REPORTS.2023,13(1):doi:10.1038/s41598-023-45747-3.
APA：
Tian Ju,Li Xiong Jie,Ma Yongshi,Mai Zhiming,Yang Yao...&Cui Xiao.(2023).Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age.SCIENTIFIC REPORTS,13,(1)
MLA：
Tian Ju,et al."Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age".SCIENTIFIC REPORTS 13..1(2023)

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