Effectiveness of Shenshu Guanxin recipe granules for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial
机构：[1]Department of Traditional Chinese Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.[2]Department of Cardiology, Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.广东省中医院[3]Department of Cardiology, Dongzhimen Hosipital, Beijing 100029, China.[4]Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.深圳市康宁医院深圳医学信息中心中国医学科学院阜外医院深圳医院
To assess the effectivess of Shenshu Guanxin recipe granules (, SGR) in improving exercise tolerance and the quality of life in patients with Stable Angina Pectoris (SAP).A total of 189 patients were consecutively enrolled between December 2012 and December 2014. The included patients were randomly assigned to SGR and placebo groups. The primary endpoints included mainly the results of treadmill exercise test and Seattle Angina Questionnaire (SAQ) during 12 weeks of treatment.After 12 weeks of treatment, SGR extended the time of exercise-induced ST-segment depression of 0.1 MV, lowered the maximum ST-segment depression, and shortened the duration of ST-segment depression in patients with SAP in southern China. Besides, the study also proved that SGR could improve the quality of life and functional status of patients with SAP.SGR showed a positive effect on exercise tolerance compared with the placebo besides optimal medical therapy. Also, the study proved that SGR could improve the SAQ score of the patients.
基金：
Supported by Guangdong Medical Foundation: Exploring the
Mechanism of Shenshu Guanxin Formula in Intervention of
Myocardial Ischemia Based on MiR-24 Mediated Bim/Caspase
Apoptosis Signal Pathway (No. A2021349); and the Fundamental
Research Funds for the Central Universities: Exploring the Intervention
of Shenshu Guanxin Formula on Myocardial Ischemia Based on MiR-
24 Mediated Bim/Caspase Apoptosis Signal Pathway Mechanism
Research (No. 21621062); the Science and Technology Innovation
Projects of Shenzhen: to Study the Mechanism of Hesperidin in
Improving Heart Failure Based on Myocardial Inflammation Mediated
by MtDNA-sGAS-STING Signaling Pathway (No.
JCYJ20220530144212026)
第一作者机构：[1]Department of Traditional Chinese Medicine, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
通讯作者：
通讯机构：[4]Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.[*1]Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China
推荐引用方式(GB/T 7714)：
Xiao Jin,Bingxin WU,Huanlin WU,et al.Effectiveness of Shenshu Guanxin recipe granules for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial[J].JOURNAL OF TRADITIONAL CHINESE MEDICINE.2023,43(6):1227-1233.doi:10.19852/j.cnki.jtcm.20231008.001.
APA：
Xiao Jin,Bingxin WU,Huanlin WU&Danping XU.(2023).Effectiveness of Shenshu Guanxin recipe granules for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial.JOURNAL OF TRADITIONAL CHINESE MEDICINE,43,(6)
MLA：
Xiao Jin,et al."Effectiveness of Shenshu Guanxin recipe granules for improving exercise tolerance in patients with stable angina pectoris: a randomized, double-blind, placebo-controlled trial".JOURNAL OF TRADITIONAL CHINESE MEDICINE 43..6(2023):1227-1233
