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Biological role of long non-coding RNA KCNQ1OT1 in cancer progression

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机构： [1]Guangzhou Univ Chinese Med, Dongguan Hosp, Dongguan 523000, Peoples R China [2]Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510405, Peoples R China [3]Wuhan Fourth Hosp, Dept Anesthesiol, Wuhan 430000, Peoples R China [4]Hubei Prov Hosp Tradit Chinese Med, Dept Hlth Management Ctr, 856 Luoyu Rd, Wuhan 430070, Peoples R China [5]Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510000, Peoples R China

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关键词： Long noncoding RNA KCNQ1OT1 Cancer Signaling pathway Progression

摘要：

Long non-coding RNAs (lncRNAs) are a type of RNAs that are more than 200 nucleotides without protein-coding potential. In recent years, more and more attention has been paid to the role of lncRNAs in cancer pathogenesis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) is located on chromosome 11p15.5 with a total length of 91 kb and is highly expressed in various malignancies, which is closely related to tumor growth, lymph node metastasis, survival cycle and recurrence rate. In addition, KCNQ1OT1 is involved in the regulation of PI3K/AKT and Wnt/beta-catenin signaling pathways. In this review, the mechanism and related progress of KCNQ1OT1 in different cancers were reviewed. It was found that KCNQ1OT1 can stabilize mRNA expression through sponging miRNA, which not only induced tumor cell proliferation, migration, invasion, drug resistance, epithelialmesenchymal transition (EMT) and inhibited cell apoptosis in vitro, but also promoted tumor growth and metastasis in vivo. Therefore, as a new biomarker and therapeutic target, KCNQ1OT1 has broad prospects for the diagnosis and treatment of different cancers.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 1 区药学 2 区医学：研究与实验

最新[2025]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 2 区药学

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出版当年[2021]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.9 最新[2023版] 6.8 最新五年平均 7.419 出版当年[2021版] 6.581 出版当年五年平均 6.53 出版前一年[2020版] 7.5 出版后一年[2022版]

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第一作者机构： [1]Guangzhou Univ Chinese Med, Dongguan Hosp, Dongguan 523000, Peoples R China

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