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Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhong Xiaoqin[1,2] * ; Feng Wei[1,2] * ; Liu Lianjie[1,2] * ; Liu Qingping[1,2] ; Xu Qiang[1,2] ; Liu Minying[1,2] ; Liu Xiaobao[1,2] ; Xu Shudi[1,2] ; Deng Minzhen[3,4,*1] ; Lin Changsong[1,2,*2] ;
机构： [1]The First Clinical Medicine College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China [2]Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China [3]State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006, China [4]Guangdong Provincial Key Laboratory of Research on Emergency in TCM, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510120, China
出处：
DOI： 10.1016/j.intimp.2024.111487
ISSN：

关键词： Periplogenin Rheumatoid arthritis Synovial fibroblasts JAK2/3-STAT3

摘要：
Rheumatoid arthritis (RA) is an autoimmune disease that affects joints, causing inflammation, synovitis, and erosion of cartilage and bone. Periplogenin is an active ingredient in the anti-rheumatic and anti-inflammatory herb, cortex periplocae. We conducted a study using a CIA model and an in vitro model of fibroblast-like synoviocytes (FLS) induced by Tumor Necrosis Factor-alpha (TNF-α) stimulation. We evaluated cell activity, proliferation, and migration using the CCK8 test, EDU kit, and transwell assays, as well as network pharmacokinetic analysis of periplogenin targets and RA-related effects. Furthermore, we measured inflammatory factors and matrix metalloproteinases (MMPs) expression using ELISA and qRT-PCR assays. We also evaluated joint destruction using HE and Safranin O-Fast Green Staining and examined the changes in the JAK2/3-STAT3 pathway using western blot. The results indicated that periplogenin can effectively inhibit the secretion of inflammatory factors, suppress the JAK2/3-STAT3 pathway, and impede the proliferation and migration of RA FLS. Thus, periplogenin alleviated the Synovial inflammatory infiltration of RA.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：
This work is supported by grants from the National Natural Science Foundation of China (Grant No.82174301 and No.81904104), the Natural Science Foundation of Guangdong Province (Grant No.2017A030311009), the Guangzhou Basic and Applied Basic Research Foundation/ Science and Technology Program of Guangzhou City of China (Grant No.2023A03J0744), Guangdong Provincial Key Laboratory of Research on Emergency in TCM (Grant No.YN2023JZ17 and No.2023B1212060062) and the Research Fund for Zhaoyang Talents of Guangdong Provincial Hospital of Chinese Medicine (Grant No. ZY2022KY06).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]The First Clinical Medicine College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China [2]Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China
共同第一作者：
通讯作者：
通讯机构： [1]The First Clinical Medicine College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China [2]Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510405, China [3]State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006, China [4]Guangdong Provincial Key Laboratory of Research on Emergency in TCM, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510120, China [*1]State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China [*2]Department of Rheumatology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
推荐引用方式(GB/T 7714)：
Zhong Xiaoqin,Feng Wei,Liu Lianjie,et al.Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2024,128:111487.doi:10.1016/j.intimp.2024.111487.
APA：
Zhong Xiaoqin,Feng Wei,Liu Lianjie,Liu Qingping,Xu Qiang...&Lin Changsong.(2024).Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway.INTERNATIONAL IMMUNOPHARMACOLOGY,128,
MLA：
Zhong Xiaoqin,et al."Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway".INTERNATIONAL IMMUNOPHARMACOLOGY 128.(2024):111487

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