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The outcome and predictive model of allogeneic hematopoietic stem cell transplantation among elderly patients with severe aplastic anemia from the Chinese Blood and Marrow Transplant Registry Group

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机构： [1]Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China. [2]National Clinical Research Center for Hematologic Disease, Beijing, China. [3]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [4]Key Laboratory of Organ Transplantation, Ministry of Education. NHC Key Laboratory of Organ Transplantation. Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. [5]Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China. [6]Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China. [7]State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. [8]Tianjin Institutes of Health Science, Tianjin, China. [9]Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China. [10]Department of Hematology, Xiangya Hospital of Central South University, National Clinical Research Center for Geriatric Diseases, Changsha, Hunan, China. [11]Department of Hematology, the First Affiliated Hospital of Ningbo University. Ningbo, Zhejiang, China. [12]Department of Hematolgy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [13]Department of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang, Hebei, China. [14]Department of Hematology, Peking University First Hospital, Beijing, China. [15]Department of Hematology, Hematopoietic Stem Cell Transplantation Center, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Translational Medicine Center on Hematology of Fujian Medical University, Fuzhou, Fujian, China. [16]Department of Hematology, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, Shandong, China. [17]Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University. Chongqing, China. [18]Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [19]The Affliated Hospital of Shandong University of TcM, Jinan, Shandong, China. [20]Department of Hematology, Shanghai Zhaxin Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China. [21]Department of Hematology, Tangdu hospital, The air force medical university, Xi'an, China. [22]Department of Hematology, The first affiliated hospital of chongqing medical university. Chongqing, China. [23]Department of Hematology, Liaocheng People's Hospital , Liaocheng, Shandong, China. [24]Department of Hematology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China. [25]Department of Hematology, The Seventh Affiliated Hospital, Sun Yet-sen University, Shenzhen, Guangdong, China. [26]Department of Haematology, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China. [27]Department of Hematology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China. [28]Department of Hematology, Wuhan No.1 Hospital, Wuhan, Hubei, China. [29]Department of Hematology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. [30]Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China [31]Peking-Tsinghua Center for Life Sciences, Beijing, China.

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Allogeneic haematopoietic stem cell transplantation (allo-HSCT) remains a first-line therapeutic option for younger patients with severe aplastic anaemia (SAA)(1). The elderly age has been proven to be associated with relatively higher mortality of allo-HSCT treating SAA, partly due to poorer organ function(2). Data from the European Society for Blood and Marrow Transplant (EBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) have demonstrated that allo-HSCT led to a 3-year overall survival (OS) of 56% among 499 SAA patients older than 50 years(3). In this large-size sample study, all transplants were from matched sibling (MSD) or matched unrelated donors (MUD) but lacked haploidentical donors(3). In recent decades, haploidentical donor (HID) HSCT has made great advances for SAA, and the upper limit of age among SAA recipients has been continuously broken (4, 5). A retrospective study indicated comparable survival outcomes between transplantation from HID and MSD or unrelated donors (URD) for SAA patients aged 40 years and older, with a median age of 43-48.5 years and 3-year OS of 86.7-100% among the three groups(6). However, the outcomes of allo-HSCT for SAA patients older than 50 years, especially including HID-HSCT, have rarely been reported.

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出版当年[2023]版：

大类 | 1 区

医学

小类 | 2 区血液学

最新[2025]版：

大类 | 1 区

医学

小类 | 2 区血液学

第一作者：

第一作者机构： [1]Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China. [2]National Clinical Research Center for Hematologic Disease, Beijing, China.

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通讯作者：

通讯机构： [1]Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China. [2]National Clinical Research Center for Hematologic Disease, Beijing, China. [30]Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China [31]Peking-Tsinghua Center for Life Sciences, Beijing, China.

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