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Naringenin protects myocardial ischemia/reperfusion injury by regulating miR-24-3p to inhibit cell death-inducing p53 target 1 expression

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机构: [1]Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, P. R. China. [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, P. R. China. [3]Department of Traditional Chinese Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, P. R. China.
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关键词: Myocardial ischemia/reperfusion injury Naringenin miR-24-3p Cell deathinducing p53 target 1 Apoptosis

摘要:
Myocardial ischemia/reperfusion (I/R) causes serious threats to human life. Naringenin, a polyphenolic compound naturally occurring in citrus fruit, has cardioprotective effects against myocardial I/R injury. Besides, miR-24-3p is also reported to have cardioprotective effects. We intended to explore whether the cardioprotective effects of naringenin relate to miR-24-3p and its underlying mechanism. In this study, we used an in vivo rat myocardial I/R model and an in vitro cardiomyocyte H9c2 hypoxia/reoxygenation (H/R) model. Myocardial injury was detected by hematoxylin-eosin staining and ELISA for creatine kinase (CK), malondialdehyde (MDA), and lactate dehydrogenase (LDH). miR-24-3p and cell death inducing p53 target 1 (Cdip1) mRNA expressions were examined by RT-PCR. We find that naringenin pretreatment significantly relieves myocardial I/R injury, reduces LDH, CD, and MDA levels, and increases miR-24-3p expression. Furthermore, miR-24-3p alleviates myocardial I/R injury partially through regulating Cdip1. Moreover, naringenin protects myocardial I/R injury partially by regulating miR-24-3p to inhibit Cdip1 expression. In conclusion, our data suggest naringenin protects myocardial I/R injury partially through miR-24-3p/Cdip1 axis.

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出版当年[2023]版:
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理 4 区 生理学
最新[2025]版:
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理 4 区 生理学
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第一作者机构: [1]Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, P. R. China.
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