机构：[1]Dongguan Key Laboratory of Screening and Research of Anti-inflammatory Ingredients in Chinese Medicine, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.[2]Guangdong Key Laboratory of Nanomedicine, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.[3]Department of Gastroenterology, the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan 523000, China.[4]Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China.[5]Institute of Nano Biomedicine and Engineering, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, China.
In recent years, tumor catalytic therapy based on nanozymes has attracted widespread attention. However, its application is limited by the tumor hypoxic microenvironment (TME). In this study, we developed oxygen-supplying magnetic bead nanozymes that integrate hemoglobin and encapsulate the photosensitizer curcumin, demonstrating reactive oxygen species (ROS)-induced synergistic breast cancer therapy. Fe3O4 magnetic bead-mediated catalytic dynamic therapy (CDT) generates hydroxyl radicals (˙OH) through the Fenton reaction in the tumor microenvironment. The Hb-encapsulated Fe3O4 magnetic beads can be co-loaded with the photosensitizer/chemotherapeutic agent curcumin (cur), resulting in Fe3O4-Hb@cur. Under hypoxic conditions, oxygen molecules are released from Fe3O4-Hb@cur to overcome the TME hypoxia, resulting in comprehensive effects favoring anti-tumor responses. Upon near-infrared (NIR) irradiation, Fe3O4-Hb@cur activates the surrounding molecular oxygen to generate a certain amount of singlet oxygen (1O2), which is utilized for photodynamic therapy (PDT) in cancer treatment. Meanwhile, we validated that the O2 carried by Hb significantly enhances the intracellular ROS level, intensifying the catalytic therapy mediated by Fe3O4 magnetic beads and inflicting lethal damage to cancer cells, effectively inhibiting tumor growth. Therefore, significant in vivo synergistic therapeutic effects can be achieved through catalytic-photodynamic combination therapy.
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外文
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出版当年[2023]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
最新[2025]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
第一作者：
第一作者机构：[1]Dongguan Key Laboratory of Screening and Research of Anti-inflammatory Ingredients in Chinese Medicine, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
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推荐引用方式(GB/T 7714)：
Cai Xinyi,Xu Tiantian,Ding Rui,et al.Oxygen self-supplying small size magnetic nanoenzymes for synergistic photodynamic and catalytic therapy of breast cancer[J].Nanoscale.2024,doi:10.1039/d3nr05289c.
APA：
Cai Xinyi,Xu Tiantian,Ding Rui,Zhang Dou,Chen Guiquan...&Yin Ting.(2024).Oxygen self-supplying small size magnetic nanoenzymes for synergistic photodynamic and catalytic therapy of breast cancer.Nanoscale,,
MLA：
Cai Xinyi,et al."Oxygen self-supplying small size magnetic nanoenzymes for synergistic photodynamic and catalytic therapy of breast cancer".Nanoscale .(2024)
