Abstract BACKGROUND：At present．when compared with the conventional suction drainage．the advantages of autologous blood transfusion drainage af【er total knee arthroplasty have not been clear yet and need evidence of evidence．based medicine to support． OBJECTlVE：Based on the existing evidence of evidence．based medicine．compared with the conventionaI suction drainage，we evaluated the eficiency，safety，and potentiaI advantages of autologous blood transfusion drainage in totaI knee arthroplasty． METHODS：We performed a systematic Iiterature search of PubMed．Embase．and the Cochrane Library：alI randomized controlled trials that compared the efects of autologous blood transfusion drainage and conventional suction drainage in totaI knee arthroplasty were included for meta-analysis． RESULTS AND CONCLUSION：Twelve randomized controlled trials。including 1 1 1 9 cases(556 cases for autologous blood transfusion drainage and 563 cases for conventionaI suction drainage)． were identified．Meta．analysis results demonstrated that patients in the autologous blood transfusion drainage group benefitted frOm a Iower blood transfusion rate(OR=O．28，95％CI： O．1 4-0．55．Z=3．67，P=0．000 2)and a Iower number of units transfused per patient(weighted mean difference=-0．56，95％Cf：一0．79--0．33．Z=4．71，P<0．000 01)．Wound complications，deep vein thrombosis，febrile complications，post-operative hemoglobin on days 5-8，drainage volume，and hospital stay length did not significantly differ between autologous blood transfusion drainage and conventional suction drainage groups(P>0．O5)．This meta—analysis suggests that autologous blood transfusion drainage ofers a safe and e仟icient alternative to conventionaI suction drainage with a lower blood transfusion rate and a smaller number of units transfused per patient．