[Objective] To observe the effect of kidney-tonifying traditional Chinese herbs Yizhen Ⅰ,Ⅱ capsules on periovulatory ovarian interstitial blood flow in infertile women of advanced reproductive age.[Methods]Forty-eight infertile women of advanced reproductive age were randomly divided into two group:the Chinese medicine group (26 eases) was treated with,YizhenⅠ,Ⅱ capsules (treatment group) and the control group (22 cases) treated with clomiphene.The follicle size,morphology and ovarian interstitial blood flow were observed by transvaginal Doppler ultrasound.[Results] Endometrial thickness in different periods had no significant change before and after the treatment in both groups.In the treatment group,follicle growth rate after treatment was accelerated than before treatment,follicle was full translucent,small follicle ovulation noticeably reduced.Meanwhile in the treatment group,resistive index (RI) and pulsatility index (PI) were significantly reduced during the 12th ～16th day of menstrual cycle,the difference before and after treatment was significant (P ＜0.05).However,in the control group,RI and PI had no significant change before and after treatment.Mter Chinese medicine treatment,RI and PI decreased significantly,compared with the control group (P＜0.05).The pregnancy rate was 36.3% in the treatment group,23.52% in the control group.The difference between the two groups was significant (P＜0.05).[ Conclusions]The change of ovarian interstitial blood flow in periovulatory period indirectly reflects the improvement of ovum quabty and ovarian reserve.The effect that kidney-tonifying traditional Chinese herbs can improve ovum quality and ovarian reserve,can be indirectly reflected by the changes of follicle growth and ovarian interstitial blood flow under transvaginal Doppler ultrasound.