机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China广东省中医院[2]School of Pharmacy, Guangdong Pharmaceutical University, Waihuan Donglu, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China
The development of solubilizers with high efficiency, high safety and simple technology is one of the important fields in modern pharmaceutical industry. Our previous study found that vinegar baked Radix Bupleurum polysaccharides (VBCP) was a potential candidate. This study aimed to clarify which polysaccharide in VBCP had solubility enhancement effect and its solubilizing mechanism. Here, we reported that a novel acidic branched polysaccharide from VBCP, VBCP-3-A, which was non-toxic and had high solubility to baicalin and rhein. It was much better than that of Tween 80. The solubilization mechanism might be that VBCP-3-A self-assembled to form micelle-like aggregates in water, which can encapsulate water-insoluble constituents through the interaction of both hydrogen bonding and hydrophobic forces. in vivo pharmacokinetic study showed that VBCP-3-A increased C-max and AUC((0,t)) of baicalin and rhein. Those results suggested that VBCP-3-A was a potential solubilizer with high efficiency and high safety.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573612, 81703798]; Science and Technology Planning Project of Guangdong Province of China [2017A020211013]
第一作者机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Ya,Wan Peng,Wang Jinqiu,et al.Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine[J].CARBOHYDRATE POLYMERS.2020,229:doi:10.1016/j.carbpol.2019.115473.
APA：
Zhao, Ya,Wan, Peng,Wang, Jinqiu,Li, Ping,Hu, Qiaohong&Zhao, Ruizhi.(2020).Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine.CARBOHYDRATE POLYMERS,229,
MLA：
Zhao, Ya,et al."Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine".CARBOHYDRATE POLYMERS 229.(2020)
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