机构：[1]Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China[2]Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China[3]National Clinical Research Study Center for Kidney Disease[4]State Key Laboratory for Organ Failure Research[5]Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China[6]Department of Cardiology, Peking University First Hospital, Beijing, China[7]School of Health Administration, Anhui University, Hefei, China[8]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China广东省中医院[9]Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China[10]Department of Cardiology, First People’s Hospital, Lianyungang, China[11]Department of Neurology, First People’s Hospital, Lianyungang, China
The relationship between electrocardiographic-left ventricular hypertrophy (ECG-LVH) and stroke has been well established in the Western population with limited information in the Chinese population. This study evaluated the association between ECG-LVH and stroke outcome. A total of 19,815 (95.7%) subjects from the China Stroke Primary Prevention Trial (CSPPT) with baseline ECG were included. ECG-LVH by sex-unspecific Sokolow-Lyon criteria was detected in 1599 participants (8.1%) at baseline. After a mean follow-up of 4.5 years, 605 (3.1%) subjects were detected with new-onset stroke over the total population, baseline ECG-LVH was present in 72 (4.5%) of them during follow-up. After adjusting for various cofounders, ECG-LVH remained as an independent risk factor for stroke events in the total population (HR = 1.43; 95% CI, 1.10-1.84; P = 0.007) and male population (HR = 1.47; 95% CI, 1.07-2.03; P = 0.019). Subgroup analysis showed that baseline ECG-LVH was a risk factor for stroke in individuals younger than 65 years of age(HR = 1.80, 95% CI, 1.31-2.47 vs. HR = 1.02, 95% CI, 0.66-1.59, P value for interaction = 0.047). In summary, LVH diagnosed by ECG is associated with an excess risk for stroke in Chinese hypertensive population, especially in the age group of younger than 65 years.
基金：
National Science and Technology
Major Projects Specialized for “Precision Medicine Research”
during the 13th Five-Year Plan Period (No. 2016YFC0903100); the
State Key Program of National Natural Science Foundation of China
(No. 81530015 to Y.G.L); Projects of National Natural Science
Foundation of China (Nos. 81473052 and 81402735 to Y.G.L); the
Science, Technology and Innovation Committee of Shenzhen (No.
JCYL20130401162636527); the Department of Development and
Reform, Shenzhen Municipal Government (No. SFG 20201744); the
Special Project on the Integration of Industry, Education and Research
of Guangdong Province (No. 2011A091000031); and the Science and
Technology Planning Project of Guangdong Province, China (No.
2014B090904040).
第一作者机构：[1]Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Yan,Huang Xiao,Zhang Peng-Pai,et al.Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults[J].JOURNAL OF HUMAN HYPERTENSION.2020,34(4):286-292.doi:10.1038/s41371-018-0155-x.
APA：
Zhao, Yan,Huang, Xiao,Zhang, Peng-Pai,Bao, Huihui,Yu, Yaren...&Li, Yi-Gang.(2020).Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults.JOURNAL OF HUMAN HYPERTENSION,34,(4)
MLA：
Zhao, Yan,et al."Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults".JOURNAL OF HUMAN HYPERTENSION 34..4(2020):286-292
