机构：[1]Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, Guangdong, China深圳市康宁医院深圳医学信息中心[2]School of Life Sciences, Northwestern Polytechnical University,Xi’an 710072, Shaanxi, China[3]Key Laboratory for Space Bioscience and Biotechnology,Northwestern Polytechnical University, Xi’an 710072, Shaanxi,China[4]Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, China[5]Department of Spine Surgery, Shenzhen People’s Hospital,Shenzhen 518000, Guangdong, China深圳市康宁医院深圳市人民医院深圳医学信息中心
Iron is one of the important trace elements in life activities. Abnormal iron metabolism increases the incidence of many skeletal diseases, especially for osteoporosis. Iron metabolism plays a key role in the bone homeostasis. Disturbance of iron metabolism not only promotes osteoclast differentiation and apoptosis of osteoblasts but also inhibits proliferation and differentiation of osteoblasts, which eventually destroys the balance of bone remodeling. The strength and density of bone can be weakened by the disordered iron metabolism, which increases the incidence of osteoporosis. Clinically, compounds or drugs that regulate iron metabolism are used for the treatment of osteoporosis. The goal of this review summarizes the new progress on the effect of iron overload or deficiency on osteoporosis and the mechanism of disordered iron metabolism on osteoporosis. Explaining the relationship of iron metabolism with osteoporosis may provide ideas for clinical treatment and development of new drugs.
基金：
Fundamental Research Funds for the Central Universities [3102017OQD111]; National Natural Science Foundation of China [51777171]; Science and Technology Planning Project of Shenzhen of China [JCYJ20170412140904406]; the Northwestern Polytechnical University Foundation for Fundamental Research [3102018JGC012]
第一作者机构：[1]Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, Guangdong, China[2]School of Life Sciences, Northwestern Polytechnical University,Xi’an 710072, Shaanxi, China[3]Key Laboratory for Space Bioscience and Biotechnology,Northwestern Polytechnical University, Xi’an 710072, Shaanxi,China
通讯作者：
通讯机构：[1]Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, Guangdong, China[3]Key Laboratory for Space Bioscience and Biotechnology,Northwestern Polytechnical University, Xi’an 710072, Shaanxi,China
推荐引用方式(GB/T 7714)：
Che Jingmin,Yang Jiancheng,Zhao Bin,et al.The Effect of Abnormal Iron Metabolism on Osteoporosis[J].BIOLOGICAL TRACE ELEMENT RESEARCH.2020,195(2):353-365.doi:10.1007/s12011-019-01867-4.
APA：
Che, Jingmin,Yang, Jiancheng,Zhao, Bin,Zhang, Ge,Wang, Luyao...&Shang, Peng.(2020).The Effect of Abnormal Iron Metabolism on Osteoporosis.BIOLOGICAL TRACE ELEMENT RESEARCH,195,(2)
MLA：
Che, Jingmin,et al."The Effect of Abnormal Iron Metabolism on Osteoporosis".BIOLOGICAL TRACE ELEMENT RESEARCH 195..2(2020):353-365
