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Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis

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机构: [1]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [2]Department of Radiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China [3]Department of Neurology, Shaanxi Provincial People’s Hospital, The Affiliated Hospital of Northwestern Polytechnical University, Xi’an, China [4]Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou, China [5]Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
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关键词: MFG-E8 Amyotrophic lateral sclerosis Cerebrospinal fluid Disease severity

摘要:
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease resulting in the dysfunction of upper and lower motor neurons. Biomarkers in fluid have been used to monitor the disease and its progression. Milk fat globule-EGF factor 8 (MFG-E8) is an inflammation modulator, which is involved in the pathogenesis of neurodegenerative diseases. We here took this study to evaluate the predictive value of MFG-E8 in ALS. Methods This study consisted of 19 patients with ALS and 15 healthy controls. Cerebrospinal fluid (CSF) were collected from all participants and tested for the levels of MFG-E8, neurofilament light (NFL), and heavy chain (NFH). The correlations between MFG-E8 and NFL, NFH, ALS severity, cognitive status, and forced vital capacity (FVC) were analyzed. Results We found that MFG-E8 performs well in distinguishing ALS from controls, with relatively higher level of MFG-E8 in ALS subjects, than controls. Moreover, MFG-E8 negatively correlated with the revised ALS function rating scale (ALS-FRS), but not with the levels of NFL and NFH, disease duration, progression rate, mini-mental state examination (MMSE), and FVC. Conclusions The study proved that CSF MFG-E8 helps distinguish ALS from controls. However, the protein in CSF negatively predicted disease severity.

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出版当年[2019]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
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出版当年[2018]版:
Q3 NEUROSCIENCES Q3 CLINICAL NEUROLOGY
最新[2024]版:
Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

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第一作者机构: [1]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
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