机构:[1]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China广东省中医院[2]Department of Radiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China深圳市康宁医院深圳医学信息中心中国医学科学院阜外医院深圳医院[3]Department of Neurology, Shaanxi Provincial People’s Hospital, The Affiliated Hospital of Northwestern Polytechnical University, Xi’an, China[4]Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou, China[5]Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease resulting in the dysfunction of upper and lower motor neurons. Biomarkers in fluid have been used to monitor the disease and its progression. Milk fat globule-EGF factor 8 (MFG-E8) is an inflammation modulator, which is involved in the pathogenesis of neurodegenerative diseases. We here took this study to evaluate the predictive value of MFG-E8 in ALS. Methods This study consisted of 19 patients with ALS and 15 healthy controls. Cerebrospinal fluid (CSF) were collected from all participants and tested for the levels of MFG-E8, neurofilament light (NFL), and heavy chain (NFH). The correlations between MFG-E8 and NFL, NFH, ALS severity, cognitive status, and forced vital capacity (FVC) were analyzed. Results We found that MFG-E8 performs well in distinguishing ALS from controls, with relatively higher level of MFG-E8 in ALS subjects, than controls. Moreover, MFG-E8 negatively correlated with the revised ALS function rating scale (ALS-FRS), but not with the levels of NFL and NFH, disease duration, progression rate, mini-mental state examination (MMSE), and FVC. Conclusions The study proved that CSF MFG-E8 helps distinguish ALS from controls. However, the protein in CSF negatively predicted disease severity.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81701061, 81901084]; Medical Scientific Research Foundation of Guangdong Province of China [A2019114]; Shaanxi Provincial Natural Science Foundation
第一作者机构:[1]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
通讯作者:
推荐引用方式(GB/T 7714):
Biying Yang,Yongshun Wu,Yihao Wang,et al.Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis[J].NEUROLOGICAL SCIENCES.2020,41(10):2915-2920.doi:10.1007/s10072-020-04416-3.
APA:
Biying Yang,Yongshun Wu,Yihao Wang,Huili Yang,Baoxin Du...&Xiaolei Shi.(2020).Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis.NEUROLOGICAL SCIENCES,41,(10)
MLA:
Biying Yang,et al."Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis".NEUROLOGICAL SCIENCES 41..10(2020):2915-2920