详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China [2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China [3]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

出处：

DOI：

ISSN：

关键词： quercetin diabetic encephalopathy SIRT1 ER stress

摘要：

Studies have shown that diabetes is an important risk factor for cognitive dysfunction, also called diabetic encephalopathy (DE). Quercetin has been reported to be effective in improving cognitive dysfunction in DE. But its detailed mechanism is still ambiguous. In this study, we used db/db mice to investigate whether quercetin could activate SIRT1 and inhibit ER pathways to improve DE. Behavioral tests (Morris water maze and new objects) showed that quercetin (70 mg/kg) can effectively improve the learning and memory ability in db/db mice. OGTT and ITT tests indicated that quercetin could alleviate impaired glucose tolerance and insulin resistance in db/db mice. Western blot analysis and Nissl staining showed that quercetin can improve the expression of nerve and synapse-associated proteins (PSD93, PSD95, NGF and BDNF) and inhibit neurodegeneration. Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1 alpha, ATF6, elF2 alpha, BIP and PDI). In addition, oxidative stress levels were significantly reduced after quercetin treatment. In conclusion, current experimental results indicated that SIRT1/ER stress is a promising mechanism involved in quercetin-treated diabetic encephalopathy.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区老年医学 3 区细胞生物学

最新[2025]版：

无

JCR分区：

出版当年[2018]版：

Q1 GERIATRICS & GERONTOLOGY Q1 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.515 出版当年[2018版] 5.543 出版当年五年平均 5.179 出版前一年[2017版] 4.831 出版后一年[2019版]

第一作者：

第一作者机构： [1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China [2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China

通讯作者：

通讯机构： [1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China [2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice [2]Carnosine Improves Cognitive Impairment Through Promoting SIRT6 Expression and Inhibiting Endoplasmic Reticulum Stress in a Diabetic Encephalopathy Model. [3]Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats. [4]Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress. [5]Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux. [6]Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway [7]Taohong siwu decoction ameliorates cognitive dysfunction through SIRT6/ER stress pathway in Alzheimer's disease [8]Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1 [9]Betulinic acid chemosensitizes breast cancer by triggering ER stress-ediated apoptosis by directly targeting GRP78 [10]Astragaloside IV Reduces Cerebral Ischemia/Reperfusion-Induced Blood-Brain Barrier Permeability in Rats by Inhibiting ER Stress-Mediated Apoptosis.