机构：[1]The Second Clinical College of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Yuexiu District, Guangzhou 510120, China 大德路总院广东省中医院[2]Department of Rheumatology and Immunology, Guangdong Provincial Hospital of Chinese Medicine, No. 55, Neihuanxi Road, Higher Education Mega Center, Guangzhou 510006, China 大德路总院风湿科风湿免疫研究团队广东省中医院[3]China-Australia International Research Centre for Chinese Medicine, RMIT University, P.O. Box 71, Bundoora, Victoria 3083, Australia
Background. Rheumatoid arthritis (RA) is an autoimmune disease characterized by multijoint swelling, pain, and destruction of the synovial joints. Treatments are available but new therapies are still required. One source of new therapies is natural products, including herbs used in traditional medicines. In China and neighbouring countries, natural products have been used throughout recorded history and are still in use for RA and its symptoms. This study used text-mining of a database of classical Chinese medical books to identify candidates for future clinical and experimental investigations of therapeutics for RA. Methods. The database Encyclopaedia of Traditional Chinese Medicine (Zhong Hua Yi Dian) includes the full texts of over 1,150 classical books. Eight traditional terms were searched. All citations were assessed for relevance to RA. Results and Conclusions. After removal of duplications, 3,174 citations were considered. After applying the exclusion and inclusion criteria, 548 citations of traditional formulas were included. These derived from 138 books written from 206 CE to 1948. These formulas included 5,018 ingredients (mean, 9 ingredients/formula) comprising 243 different natural products. When these text-mining results were compared to the 18 formulas recommended in a modern Chinese Medicine clinical practice guideline, 44% of the herbal formulas were the same. This suggests considerable continuity in the clinical application of these herbs between classical and modern Chinese medicine practice. Of the 15 herbs most frequently used as ingredients of the classical formulas, all have received research attention, and all have been reported to have anti-inflammatory effects. Two of these 15 herbs have already been developed into new anti-RA therapeutics-sinomenine from Sinomenium acutum (Thunb.) Rehd. & Wils and total glucosides of peony from Paeonia lactiflora Pall. Nevertheless, there remains considerable scope for further research. This text-mining approach was effective in identifying multiple natural product candidates for future research.
基金：
the National Key Research and Development Project (nos.
2018YFC1705200 and 2018YFC1705203) and the China-
Australia International Research Centre for Chinese Medicine
(CAIRCCM), a joint initiative of RMIT University,
Australia, and Guangdong Provincial Academy of Chinese
Medical Sciences, China, and the Foundation for Chinese
Medicine and Technology Research of Guangdong Provincial
Hospital of Chinese Medicine (2017KT1820, 2016KT1571).
第一作者机构：[1]The Second Clinical College of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Yuexiu District, Guangzhou 510120, China [2]Department of Rheumatology and Immunology, Guangdong Provincial Hospital of Chinese Medicine, No. 55, Neihuanxi Road, Higher Education Mega Center, Guangzhou 510006, China
通讯作者：
通讯机构：[1]The Second Clinical College of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Yuexiu District, Guangzhou 510120, China [2]Department of Rheumatology and Immunology, Guangdong Provincial Hospital of Chinese Medicine, No. 55, Neihuanxi Road, Higher Education Mega Center, Guangzhou 510006, China
推荐引用方式(GB/T 7714)：
Xia Xuan,May Brian H.,Zhang Anthony Lin,et al.Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2020,2020:doi:10.1155/2020/7531967.
APA：
Xia, Xuan,May, Brian H.,Zhang, Anthony Lin,Guo, Xinfeng,Lu, Chuanjian...&Huang, Qingchun.(2020).Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,
MLA：
Xia, Xuan,et al."Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020.(2020)
