Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature
机构：[1]Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510515, China广东省中医院[2]Department of Critical Care Medicine, the FirstAffiliated Hospital of Guizhou University of Chinese Medicine, Guiyang550001, China[3]Department of Critical Care Medicine, General Hospital ofSouthern Theater Command of PLA, Guangzhou 510010, China[4]KeyLaboratory of Hot Zone Trauma Care and Tissue Repair of PLA, GeneralHospital of Southern Theater Command of PLA, Guangzhou 510010, China
Background Intracranial infection after craniotomy is one of the most serious postoperative complications, especially multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacterial meningitis, and strongly affects the prognosis of patients. Current treatment experience regarding these infections is scarce. Case presentation We report a case of severe intracranial infection of XDR Acinetobacter baumannii (A. baumannii) that was treated by intravenous (IV) injection, sequential intraventricular (IVT) injection of tigecycline and polymyxin B, and other anti-infective drugs. Good results were obtained, and the patient was eventually discharged from the hospital. This case is characterized by intracranial infection. Conclusions The polymyxin B IV + IVT pathway is an ideal treatment strategy for XDR A. baumannii. The tigecycline IVT pathway is also a safe treatment option.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571940, 81741125]; Guangzhou Science and Technology Planning Project of China [201504281714528]; PLA Logistics Research Project of China [CWH17L020, 17CXZ008, 18CXZ030]
第一作者机构：[1]Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510515, China[2]Department of Critical Care Medicine, the FirstAffiliated Hospital of Guizhou University of Chinese Medicine, Guiyang550001, China
通讯作者：
通讯机构：[3]Department of Critical Care Medicine, General Hospital ofSouthern Theater Command of PLA, Guangzhou 510010, China[4]KeyLaboratory of Hot Zone Trauma Care and Tissue Repair of PLA, GeneralHospital of Southern Theater Command of PLA, Guangzhou 510010, China
推荐引用方式(GB/T 7714)：
Zhong Li,Shi Xue-Zhi,Su Lei,et al.Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature[J].MILITARY MEDICAL RESEARCH.2020,7(1):doi:10.1186/s40779-020-00253-9.
APA：
Zhong, Li,Shi, Xue-Zhi,Su, Lei&Liu, Zhi-Feng.(2020).Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature.MILITARY MEDICAL RESEARCH,7,(1)
MLA：
Zhong, Li,et al."Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature".MILITARY MEDICAL RESEARCH 7..1(2020)
医学