机构：[1]The Rehabilitation Medicine Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China江苏省人民医院[2]The Second Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China[3]The Teaching and Research Department of Statistics, Nanjing Medical University, Nanjing, Jiangsu, China[4]Rehabilitation Center, The Second Affiliated Hospital of HaiNan Medical University, Haikou, Hainan, China[5]The Rehabilitation Department, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China[6]The Acupuncture Rehabilitation Department, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China江苏省人民医院[7]Rehabilitation Center, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Haerbin, Heilongjiang, China[8]The Rehabilitation Department, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangdong, China广东省中医院[9]The Rehabilitation Department, Tongji Medical College Huazhong University of science & Technology, Wuhan, Hubei, China[10]The Neurological Rehabilitation Department, Shanghai University of Traditional Chinese Medicine, Shanghai, China[11]Rehabilitation Center, Xuzhou Central Hospital, Xuzhou, Jiangsu, China[12]The Rehabilitation Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China[13]The Rehabilitation Department, Tianjin Medical University General Hospital, Tianjin, China[14]The Neurology Department, Nanjing Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China[15]The Rehabilitation Department, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, Hubei, China[16]The Rehabilitation Department, Lianyungang Chinese Medicine Hospital, Lianyungang, China[17]The Rehabilitation Department, Dongguan Kanghua Hospital, Dongguan, China
Objective To investigate the efficacy and safety of Tui Na for treating spasticity of the upper limbs of stroke patients. Design A prospective, multicenter, blinded, randomized controlled intervention study. Subjects Stroke patients with upper limb spasticity who were treated between December 2013 and February 2017 in 16 participating institutions in China were randomly assigned to receive either Tui Na plus conventional rehabilitation (Tui Na group, n = 222,) or conventional rehabilitation only (control group, n = 222). Methods Eligible adult patients (aged 18-75 years) were enrolled 1-12 months after stroke and randomly allocated in a 1:1 ratio to the two groups. Outcome assessors were blinded to treatment allocation. Muscle tone in the spastic muscles was evaluated using the Modified Ashworth Scale (MAS), and the primary endpoint was the change in MAS score over 4 weeks of treatment. Results Among patients who had experienced stroke 1-3 months before treatment, the Tui Na group experienced significantly greater reductions in MAS scores for three muscle groups than did the control group after 4 weeks of treatment. These improvements were sustained at the 3- and 6-month follow-ups. However, among patients who suffered from stroke 4-6 months and 7-12 months before treatment, the change in MAS with treatment did not differ significantly between those who did and those who did not receive Tui Na. No Tui Na-related adverse events during treatment were reported the groups. Conclusion Tui Na was effective and safe for alleviating poststroke spasticity within 1-3 months after stroke onset.
基金：
Ministry of Science and Technology of the
People’s Republic of China through the
Twelfth Five-Year National Science and
Technology Pillar Program (2013BAI10B04).
第一作者机构：[1]The Rehabilitation Medicine Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China[2]The Second Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
通讯作者：
通讯机构：[1]The Rehabilitation Medicine Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China[*1]The Department of Physical and Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing 210029, China.
推荐引用方式(GB/T 7714)：
Wang Meng,Liu Shouguo,Peng Zhihang,et al.Effect of Tui Na on upper limb spasticity after stroke: a randomized clinical trial[J].ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY.2019,6(4):778-787.doi:10.1002/acn3.759.
APA：
Wang, Meng,Liu, Shouguo,Peng, Zhihang,Zhu, Yi,Feng, Xiaodong...&Li, Jianan.(2019).Effect of Tui Na on upper limb spasticity after stroke: a randomized clinical trial.ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY,6,(4)
MLA：
Wang, Meng,et al."Effect of Tui Na on upper limb spasticity after stroke: a randomized clinical trial".ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 6..4(2019):778-787
