机构：[1]Department of Applied Chemistry, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China[2]School of Materials Science and Engineering, South China University of Technology, Guangzhou, China[3]Orthopedics Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[4]Department of Nuclear Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院深圳市中医院深圳医学信息中心
Blood vessels play an important role in bone defect repair and growth, and a critical challenge of bone defect repair is the promotion of blood vessel formation. Most of the current methods promote vascularization by adding specific growth factors, which are costly and easy to inactivate. In this study, we developed a covalently cross-linked aminated bioactive glass nanoparticle-chondroitin sulfate methacrylate (ABGN-CSMA) organic-inorganic composite hydrogel with angiogenic properties. The amino groups of the ABGNs form covalent bonds with the carboxyl groups on CSMA. Surface amination modification of BGNs not only improved the dispersion of BGNs in CSMA but also significantly improved the mechanical properties of the composite hydrogel. The largest storage modulus (1200 Pa), the largest loss modulus (560 Pa) and the strongest resistance to deformation of the hydrogel are seen at 10% concentration of ABGNs. Simultaneously, the local pH stability and sustained ion release of the composite hydrogel are conducive to cell adhesion, proliferation, and angiogenesis. This work provides evidence for the development of covalently cross-linked organic-inorganic composite hydrogels with angiogenic properties.
基金：
China Postdoctoral Science Foundation, Grant/
Award Number: 2017M622641; Natural
Science Foundation of Guangdong Province,
Grant/Award Number: 2016A030308014;
National Natural Science Foundation of China,
Grant/Award Numbers: 51702104, 31771080,
51772106; National Key R&D Program of
China, Grant/Award Numbers:
2018YFC1105301, 2018YFC1105304
第一作者机构：[1]Department of Applied Chemistry, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Applied Chemistry, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China[3]Orthopedics Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[4]Department of Nuclear Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[*1]Department of Applied Chemistry, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.[*2]Department of Nuclear Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.[*3]Orthopedics Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
