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Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China

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收录情况： ◇ SCIE

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机构： [1]Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China [2]Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China [3]Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China [4]Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China [5]Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China [6]The First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou, China [7]Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China [8]Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China [9]Wangjing Hospital of China,Academy of Chinese Medical Sciences, Beijing, China [10]The 309th Hospital of Chinese People's Liberation Army, Beijing, China [11]Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, China [12]Luoyang Zhenggu Hospital of Henan Province, Luoyang, China [13]Clinical Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China [14]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [15]School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China [16]University of Traditional Chinese Medicine, Shanghai, China

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Introduction Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis. Methods and analysis The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45-80 years old and male residents aged 50-80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：内科

JCR分区：

出版当年[2017]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 2.4 最新[2023版] 2.7 最新五年平均 2.413 出版当年[2017版] 2.801 出版当年五年平均 2.369 出版前一年[2016版] 2.376 出版后一年[2018版]

第一作者：

第一作者机构： [1]Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China [2]Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China [3]Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China

通讯作者：

通讯机构： [1]Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China [2]Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China [4]Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China [16]University of Traditional Chinese Medicine, Shanghai, China

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