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Down-regulation of microRNA-224-inhibites growth and epithelial-to-mesenchymal transition phenotype -via modulating SUFU expression in bladder cancer cells

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收录情况： ◇ SCIE

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机构： [1]Radiotherapy & Chemotherapy Dept. 2, Ningbo NO. 2 Hospital, Zhejiang, China [2]Health and Human Service Department, Xiamen Xianyue Hospital, Xiamen, China [3]Department of Urology, Guangdong Province Hospital of Traditional Chinese Medicine, Zhuhai, China [4]State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Hepatology Unit andInfectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China [5]Department of Outpatient Nanfang Hospital, Southern Medical University, Guangzhou, China [6]Department of Emergency Nanfang Hospital, Southern Medical University, Guangzhou, China [7]Cancer Hospital of Guangzhou Medical University, Guangzhou, China

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关键词： miR-224 Bladder cancer Sufu

摘要：

Aberrant expression of miR-224 is usually found in cancer studies; however, the role of miR-224 has seldom been reported in bladder cancer (BC). We explored miR-224's function and the underlying mechanism in BC. It was found that miR-224 expression was significantly up-regulated in BC tissues and cell lines. Knockdown of miR-224 decreased BC cell growth and invasion both in vitro and in vivo. We identified the SUFU protein as a downstream target of miR-224 by using luciferase and western blot assays. We proposed that miR-224 promoted BC cell growth and invasion via sustaining the activity of Hedgehog pathway, which was negatively regulated by SUFU. Taken together, our study demonstrated that miR-224 may function as an onco-miR in BC and suggested that miR-224 may be a potential therapeutic target for BC patients. (C) 2017 Published by Elsevier B.V.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 2 区应用化学 2 区高分子科学 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

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出版当年[2016]版：

Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2024]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 8.5 最新[2024版] 8.7 最新五年平均 3.671 出版当年[2016版] 3.657 出版当年五年平均 3.138 出版前一年[2015版] 3.909 出版后一年[2017版]

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第一作者机构： [1]Radiotherapy & Chemotherapy Dept. 2, Ningbo NO. 2 Hospital, Zhejiang, China

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