The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain
机构：[1]Guangdong Provincial Key Laboratory of PharmacodynamicConstituents of TCM and New Drugs Research, College ofPharmacy, Jinan University, Guangzhou 510632, People’s Republicof China[2]Pharmaceutical Department of The First Affiliated Hospital ofGuangdong Pharmaceutical University, Clinical PharmacyDepartment of Guangdong Pharmaceutical University,Guangzhou 510080, People’s Republic of China[3]Department of Pharmacy, Hui Zhou Municipal Centre Hospital,Huizhou, Guangdong, People’s Republic of China[4]Department of Endocrinology, Guangdong Provincial Hospital ofChinese Medicine, Guangzhou 510120, People’s Republic of China[5]Pharmacy Department of General Hospital of Chinese People’sArmed Police Forces, Beijing 100039, People’s Republic of China
Anxiety disorder is a serious and burdensome psychiatric illness that frequently turn into chronic clinical conditions. Puerarin have been shown to be effective in the therapy of depression. However, few studies are concerned about the anxiolytic-like effects of puerarin. The current study aimed to evaluate the anxiolytic-like effects of puerarin and its possible mechanism. To evaluate this, the behavioral tests, i.e. Vogel-type conflict test (VTCT), elevated plus-maze test (EPMT), and open-field test (OFT) were conducted. Data showed that similar to the positive-control drug sertraline (Ser) (15 mg/kg, i.g.), the anxiolytic-like effects were produced by puerarin (60 and 120 mg/kg, i.g.) in VTCT and EMPT respectively without affecting locomotor activity in OFT. Moreover, the present study also found that consistent with Ser, the levels of allopregnanolone and serotonin (5-HT) in the prefrontal cortex and hippocampus were increased by puerarin (60 and 120 mg/kg, i.g.), respectively. In summary, the present study indicated that puerarin exerted the anxiolytic-like effects, which maybe associated with normalization of 5-HT levels and biosynthesis of allopregnanolone in brain.
基金：
Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2014A030310103, 2017A030313448]; Educational Commission of Guangdong Province, China [2016KQNCX086]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81703731, 81373993, 81673634]
第一作者机构：[1]Guangdong Provincial Key Laboratory of PharmacodynamicConstituents of TCM and New Drugs Research, College ofPharmacy, Jinan University, Guangzhou 510632, People’s Republicof China[2]Pharmaceutical Department of The First Affiliated Hospital ofGuangdong Pharmaceutical University, Clinical PharmacyDepartment of Guangdong Pharmaceutical University,Guangzhou 510080, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Qiu Zhi-Kun,Zhong De-Sheng,He Jia-Li,et al.The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain[J].METABOLIC BRAIN DISEASE.2018,33(1):167-175.doi:10.1007/s11011-017-0127-9.
APA：
Qiu, Zhi-Kun,Zhong, De-Sheng,He, Jia-Li,Liu, Xu,Chen, Ji-Sheng&Nie, Hong.(2018).The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain.METABOLIC BRAIN DISEASE,33,(1)
MLA：
Qiu, Zhi-Kun,et al."The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain".METABOLIC BRAIN DISEASE 33..1(2018):167-175
