机构：[1]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China华中科技大学同济医学院附属同济医院[2]Department of Emergency Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China华中科技大学同济医学院附属同济医院[3]Department of Anesthesiology, The First Affiliated Quanzhou Hospital of Fujian Medical University, Quanzhou 362000, PR China[4]Department of Oncology, Wuhan Peritoneal Cancer Clinical Medical Research Center, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, PR China[5]Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, PR China大德路总院麻醉科大德路总院麻醉科广东省中医院
In the present study, whole genome mRNA expression profiles in cardiac ischemia regions of rats with cardiac ischemia/reperfusion injury were analyzed to identify unique target genes. A total of 544 differentially expressed genes were identified between normal and cardiac ischemia samples. Our results identified ten key genes CXCR1, GLP1R, CCL21, GRK1, oxidative stress induced growth inhibitor 1 (OSGIN1), iroquois homeobox 1 (IRX1), opioid binding protein/cell adhesion molecule-like (OPCML), gi vertical bar 672075288 vertical bar ref vertical bar XR_595614.1 vertical bar, NON-RATT008949, XR_601753.1, NONRATT008080 were related to cardiac ischemia/reperfusion injury. These candidate genes were further examined in a cardiac ischemia/reperfusion model so as to provide important therapeutic targets for the treatment of local cardiac injury.
基金：
National Natural Science Foundation of P.R. China (No. 81670240 to H.B. X, 81770283 to M.H. F), National Natural Science Foundation of Hubei Province (No. 2016CFB625 to H.B. X), and Medical innovation project in Fujian Province (No. 2017-CX-48 to S.Y. L).
第一作者机构：[1]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
通讯作者：
通讯机构：[1]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China[5]Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, PR China[*1]Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, PR China[*2]Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China.
推荐引用方式(GB/T 7714)：
Quan Wang,Zhi-Gang He,Zhi-Xiao Li,et al.Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2018,11(5):4955-4966.doi:10.1016/j.gene.2016.09.037.
APA：
Quan Wang,Zhi-Gang He,Zhi-Xiao Li,Shun-Yuan Li,Ying-Le Chen...&Hong-Bing Xiang.(2018).Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,11,(5)
MLA：
Quan Wang,et al."Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 11..5(2018):4955-4966
