机构：[1]Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China[2]Department of Ultrasound, TheGeneral Hospital of Chinese People’s Armed Police Forces, Beijing, China[3]Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, TheThird Affiliated Hospital of Sun Yat-sen University, Guangzhou, China中山大学附属第三医院[4]Department of Ultrasound, Third People’s Hospital of Longgang District of Shenzhen,Shenzhen, China深圳市康宁医院深圳医学信息中心[5]Functional Examination Department of Children’s Hospital, Lanzhou University Second Hospital, Lanzhou, China[6]Ultrasound Department, The First Affiliated Hospital of Harbin Medical University, Harbin, China[7]Ultrasound Department, Guangzhou the Eighth People’s Hospital,Guangzhou, China[8]Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China中国医科大学附属盛京医院[9]Department of Ultrasonography,the First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China浙江大学医学院附属第一医院[10]Function Diagnosis Center, Beijing Youan Hospital, Affiliated toCapital Medical University, Beijing, China[11]Ultrasound Department, The Second People’s Hospital of Yunnan Province, Kunming, China[12]Ultrasound Department, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[13]Department of Medical Ultrasonics, Institute of Diagnosticand Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China中山大学附属第一医院[14]Department of Ultrasound, JiangsuProvince Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing, China
Purpose: To investigate the diagnostic performance of two-dimensional (2D) shear-wave elastography (SWE) in chronic hepatitis B. Materials and Methods: This prospective multicenter study from January 2015 to January 2016 was conducted at 12 hospitals and included 654 participants with chronic hepatitis B who had undergone liver biopsy and 2D SWE examination. Participants were divided into chronic infection and chronic hepatitis groups. The diagnostic performance of 2D SWE was compared with the aspartate amino transferase-to-platelet ratio index (APRI), the Fibrosis-4 index (FIB-4), and transient elastography (TE) by using a DeLong test and was also compared between two subgroups. Dual cutoff values for cirrhosis were determined with multilevel likelihood ratio analysis. Results: Overall, 402 participants with chronic hepatitis B were enrolled (154 with chronic infection and 248 with chronic hepatitis). The areas under the receiver operating characteristic curve of 2D SWE (0.87; 95% confidence interval [CI]: 0.83, 0.90) were higher than those of TE (0.80; 95% CI: 0.68, 0.88), APRI (0.70; 95% CI: 0.65, 0.74), and FIB-4 (0.73; 95% CI: 0.69, 0.78) in cirrhosis. The high area under the receiver operating characteristic curve (0.92; 95% CI: 0.87, 0.96) was achieved in the chronic infection group and was significantly higher than that of the chronic hepatitis group (0.84; 95% CI: 0.78, 0.88; P = .017). Dual cutoff values with the likelihood ratios below 0.1 and above 10 (8.4 kPa and 11.0 kPa to rule out and rule in a diagnosis of cirrhosis, respectively) were effectively determined in chronic infection; a total of 81.2% (125 of 154) participants with cirrhosis were definitively diagnosed. Conclusion: The performance of two-dimensional (2D) shear-wave elastography (SWE) was higher than that of other noninvasive methods. 2D SWE was most effective in ruling in and ruling out cirrhosis in participants with chronic infection, which may prompt antiviral treatment. (c) RSNA, 2018
第一作者机构：[1]Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China[2]Department of Ultrasound, TheGeneral Hospital of Chinese People’s Armed Police Forces, Beijing, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yongyan Gao,Jian Zheng,Ping Liang,et al.Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A Prospective Multicenter Study[J].RADIOLOGY.2018,289(2):407-415.doi:10.1148/radiol.2018172479.
APA：
Yongyan Gao,Jian Zheng,Ping Liang,Minghui Tong,Jiabing Wang...&Rongqin Zheng.(2018).Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A Prospective Multicenter Study.RADIOLOGY,289,(2)
MLA：
Yongyan Gao,et al."Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A Prospective Multicenter Study".RADIOLOGY 289..2(2018):407-415
医学