机构：[a]Nephrology Department, Shaanxi Province Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi, China[b]Emergency Department,Xi’an Central Hospital, Xi’an, Shaanxi, China[c]Key Laboratory of Trace Elements and Endemic Diseases, Institute of Endemic Diseases,National Health and Family Planning Commission of the People’s Republic of China, Xi’an Jiaotong University Health Science Center,Xi’an, Shaanxi, China[d]Nephrology Department, Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou,Guangdong, China广东省中医院[e]Pure and Applied Biochemistry, Lund University, Lund, Sweden
Objectives: The effects of regional characteristics of IgAN patients in different areas of China were investigated. Methods: Patients who were identified to have primary IgAN by renal biopsy diagnosis were recruited both from Shaanxi province hospital of traditional Chinese medicine and Guangdong province hospital of traditional Chinese medicine. Besides renal histopathology data, a number of clinical and laboratory data were collected. Results: It was shown that the frequency of the patients with no mucosal infection in the urinary tract was higher in the Guangzhou group, while the frequencies of upper respiratory tract and biliary infections were lower when compared with those in the Xi'an group. Serum uric acid, alexin C3, creatinine and serum cholesterol concentrations were increased in the Guangzhou group, while triglyceride, glomerular filtration rate, and urine red blood cell count level decreased. IgA + IgM + C3 and IgA + IgG + IgM + C3 were found in most patients of the Xi'an group, whereas IgA + C3, IgA + IgM + C3 and IgA were more frequent in the Guangzhou group. Conclusion: It was found that differential environment, life habits and patterns in the two investigated areas obviously may influence the variable characteristics of IgAN patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673115]; Huimin Project of Ministry of Science and Technology of China [2012GS610101]; Department of Health of Shaanxi Province [2014ZD072]; Science and Technology Development Projects of Shaanxi Province [2014K11-05-05]; Clinical Study on Standardized Management Mode of Chinese Western Medicine in Chronic Kidney Disease [2017SF-207]; Project of Shaanxi Province Chinese Medicine Administration Bureau [15-SCJH024]; China Scholarship Council (CSC)China Scholarship Council
第一作者机构：[a]Nephrology Department, Shaanxi Province Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi, China
通讯作者：
通讯机构：[c]Key Laboratory of Trace Elements and Endemic Diseases, Institute of Endemic Diseases,National Health and Family Planning Commission of the People’s Republic of China, Xi’an Jiaotong University Health Science Center,Xi’an, Shaanxi, China[*a]Key Laboratory of Trace Elements and Endemic Diseases, Institute of Endemic Diseases, National Health and Family Planning Commission of the People’s Republic of China, Xi’an Jiaotong University Health Science Center’, No.76, Yanta Western Road, Xi’an, Shaanxi 710061, China
推荐引用方式(GB/T 7714)：
Ping Fan,Jianmin Song,Qun Chen,et al.The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China[J].RENAL FAILURE.2018,40(1):597-602.doi:10.1080/0886022X.2018.1532907.
APA：
Ping Fan,Jianmin Song,Qun Chen,Xiaohong Cheng,Xusheng Liu...&Bin Xie.(2018).The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China.RENAL FAILURE,40,(1)
MLA：
Ping Fan,et al."The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China".RENAL FAILURE 40..1(2018):597-602
