机构：[1]Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.大德路总院皮肤科大德路总院皮肤科广东省中医院[2]Department of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University, School of Medicine, Xi’an, China.[3]Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.[4]Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China[5]Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China. 6Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 26599, USA.
Psoriasis is a chronic inflammatory skin disease with high morbidity, poor treatment methods and high rates of relapse. Keratinocyte hyperproliferation and shortened cell cycles are important pathophysiological features of psoriasis. As a known oncogene, Yes-associated protein (YAP) plays a role in promoting cell proliferation and inhibiting cell apoptosis; however, whether YAP is involved in the pathogenesis of psoriasis remains to be determined. Amphiregulin (AREG), a transcriptional target of YAP, was found to be upregulated in psoriasis, and overexpression of AREG promoted keratinocyte proliferation. In the present study, immunohistochemistry showed that YAP expression was elevated in the skin of psoriasis patients and in the Imiquimod (IMQ) mouse model of psoriasis. Knockdown of YAP in HaCaT cells inhibited cell proliferation, caused cell cycle arrest in G0/G1 phase and promoted apoptosis. These changes in YAP-knockdown HaCaT cells were related to changes in AREG expression. We concluded that YAP may play an important role in the regulation of abnormal keratinocyte proliferation via an AREG-dependent pathway and that YAP could be a new target in the treatment of psoriasis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573055]; Fundamental Research Fund for the Central Universities; Funds of Shaanxi Province [2015KTCL03-10]; Fundamental Research Fund for Changjiang Scholars, and Innovative Research Team in University [PCSIRT: 1171]; 2nd Hospital of Xi'an Jiaotong Universitygrants from the National Natural Science Foundation of China (81573055), the
Fundamental Research Funds for the Central Universities and for Changjiang Scholars, and Innovative Research
Team in University (PCSIRT: 1171) and partially supported by Funds of Shaanxi Province (2015KTCL03-10) and
2nd Hospital of Xi’an Jiaotong University.
第一作者机构：[1]Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Jia Jinjing,Li Changji,Yang Jiao,et al.Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway[J].SCIENTIFIC REPORTS.2018,8:doi:10.1038/s41598-018-32522-y.
APA：
Jia, Jinjing,Li, Changji,Yang, Jiao,Wang, Xin,Li, Ruilian...&Zheng, Yan.(2018).Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.SCIENTIFIC REPORTS,8,
MLA：
Jia, Jinjing,et al."Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway".SCIENTIFIC REPORTS 8.(2018)
