机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China广东省中医院[2]Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, Guangzhou, China,[3]College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou, China[4]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China
The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with beta-cyclodextrin (beta-CD). The interactions between patchouli alcohol and beta-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation -infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value Delta(b)G degrees was-10.8174+/-1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81202398, 81302868]; Guangdong Provincial Science and Technology Project [20136010102006, 2014A020221035, 2015A020211025]; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2014ZHR209, YN2015MS03, YN2014ZH08, YN2015QN03]
第一作者机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Fangfang,Yang Qiuxia,Wu Lilan,et al.Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin[J].PLOS ONE.2017,12(1):doi:10.1371/journal.pone.0169578.
APA：
Xu, Fangfang,Yang, Qiuxia,Wu, Lilan,Qi, Rui,Wu, Yunshan...&Liu, Bo.(2017).Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin.PLOS ONE,12,(1)
MLA：
Xu, Fangfang,et al."Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin".PLOS ONE 12..1(2017)
