机构：[1]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospitalof Chinese Medicine), Guangzhou, China广东省中医院[2]Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China[3]Stem Cell ResearchCenter, Fujian Agriculture and Forestry University, Fuzhou, China
Parkinson's disease (PD) is the second most frequent neurodegenerative disease after Alzheimer's disease, which is characterized by a low level of dopamine being expressing in the striatum and a deterioration of dopaminergic neurons (DAn) in the substantia nigra pars compacta. Generation of PD-derived DAn, including differentiation of human embryonic stem cells, human neural stem cells, human-induced pluripotent stem cells, and direct reprogramming, provides an ideal tool to model PD, creating the possibility of mimicking key essential pathological processes and charactering single-cell changes in vitro. Furthermore, thanks to the understanding of molecular neuropathogenesis of PD and new advances in stem-cell technology, it is anticipated that optimal functionally transplanted DAn with targeted correction and transgene-free insertion will be generated for use in cell transplantation. This review elucidates stem-cell technology for modeling PD and offering desired safe cell resources for cell transplantation therapy.
基金：
National Natural
Science Foundation of China (Grant no. 31271595
to Tongxiang Lin), Key Project of Chinese National
Programs for Fundamental Research and
Development (973 Programs; 2013CB9669002 to
T. Lin). This work was also supported by Science
and Technology Department of Guangdong Province
China (2015A020212032 to T. Lin), Guang-dong Provincial Hospital of Chinese Medicine
(YK2013B2N08 to T. Lin),Medical Research Fund
of Guangdong Province (B2014257), Science
Popularization Project of Haizhu District in
Guangzhou (KP2013(TJ)-24), and Scientific Research
Initiation Project of Southern Medical University
(PY2014N071).
基金编号：Grant no. 31271595
to Tongxiang Lin
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区生物工程与应用微生物2 区医学：研究与实验3 区遗传学
最新[2025]版：
大类|3 区医学
小类|2 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验
JCR分区：
出版当年[2015]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITY
最新[2023]版：
Q1GENETICS & HEREDITYQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospitalof Chinese Medicine), Guangzhou, China[2]Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospitalof Chinese Medicine), Guangzhou, China[2]Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China[3]Stem Cell ResearchCenter, Fujian Agriculture and Forestry University, Fuzhou, China[*1]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), 111 DaDe Road, Guangzhou, Guangdong 510120, China.[*2]Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510282, China
推荐引用方式(GB/T 7714)：
Zhang Qingxi,Chen Wanling,Tan Sheng,et al.Stem Cells for Modeling and Therapy of Parkinson's Disease[J].HUMAN GENE THERAPY.2017,28(1):85-98.doi:10.1089/hum.2016.116.
APA：
Zhang, Qingxi,Chen, Wanling,Tan, Sheng&Lin, Tongxiang.(2017).Stem Cells for Modeling and Therapy of Parkinson's Disease.HUMAN GENE THERAPY,28,(1)
MLA：
Zhang, Qingxi,et al."Stem Cells for Modeling and Therapy of Parkinson's Disease".HUMAN GENE THERAPY 28..1(2017):85-98
