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Oral Chinese herbal medicine versus placebo for psoriasis vulgaris: A systematic review

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机构: [1]School of Health and Biomedical Sciences, China-Australia International Research Centre for Chinese Medicine, RMIT University, Melbourne, Australia [2]Guangdong Provincial Academy of Chinese Medical Sciences and Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [3]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China
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关键词: Psoriasis herb random control trial review

摘要:
Objectives: Psoriasis is a chronic inflammatory skin disorder and the efficacy and safety of Chinese herbal medicine (CHM) treatments is unclear. This review evaluates oral CHM for psoriasis vulgaris clinical trial evidence.Design: The Cochrane Library, PubMed, EMBASE, CINAHL, AMED, CBM, CNKI, CQVIP and Wanfang databases were searched from inception to June 2015. Randomised controlled trials (RCTs) of oral CHM compared to placebo data were included and analysed using Review Manager 5.2.Results: Seven studies were included, no study utilised identical CHM intervention. Four studies data were subgrouped (decoction or capsule/pill) and pooled in meta-analysis to evaluate treatment effective rate for PASI60 or above (RR: 2.74 [0.92, 8.21] I-2=65%). Another five studies were subgrouped and evaluated for PASI score change, (MD -7.00 [-10.74, -3.27] I-2=98%). Only one study presented Dermatology Life Quality Index data, which favoured CHM (MD: -4.08 [-7.56, -0.60]). Two studies presented data on psoriasis-related inflammatory cell-signalling protein tumour necrosis factor-a (TNF-a) (MD: -4.92 [-5.31, -4.53]). No serious adverse events were reported.Conclusion: While CHMs appear to be safe and may have benefit for psoriasis, variation between CHM interventions, outcome measures and the quality of included studies limit the conclusions of this review. Further rigorous RCTs utilising reliable, validated symptom and QoL outcome measures are recommended.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 3 区 皮肤病学
最新[2025]版:
大类 | 4 区 医学
小类 | 3 区 皮肤病学
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出版当年[2015]版:
Q2 DERMATOLOGY
最新[2023]版:
Q2 DERMATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]School of Health and Biomedical Sciences, China-Australia International Research Centre for Chinese Medicine, RMIT University, Melbourne, Australia
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通讯机构: [1]School of Health and Biomedical Sciences, China-Australia International Research Centre for Chinese Medicine, RMIT University, Melbourne, Australia [2]Guangdong Provincial Academy of Chinese Medical Sciences and Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [*1]Executive Dean School of Health and Biomedical Sciences, Director, China-Australia International Research Centre for Chinese Medicine, RMIT University, PO Box 71 Bundoora, VIC. 3083, Australia
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