Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM-1/CD31 and VEGF Expression
机构：[1]Cardiovascular Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China广东省中医院[2]Emergency Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510006, China中山大学附属第一医院[3]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510080, China广东省中医院
Background. Myocardial infarction (MI) is the main cause of global mortality and morbidity despite the development of therapeutic approaches. ShenZhuGuanXin granules (SG) have been shown to possess cardioprotective effects against coronary heart disease (CHD). However, little is known about its specific mechanism. The present study aimed to investigate the therapeutic effect of SG in cardiac dysfunction and to demonstrate whether SG can promote myocardium angiogenesis by establishing a rat model of myocardial infarction with left anterior descending ligating. Methods and Results. Three days after MI, rats were randomly divided into six groups: sham group (sham), MI group (MI), MI + low dose SG (SG-L) group, MI + middle dose SG (SG-M) group, MI + high dose SG (SG-H) group, and MI + compound Danshen dropping pills (CDDP) group as a positive control. Four weeks after administration, rats underwent hemodynamics and echocardiography study. Ventricle tissues were processed for histology and immunohistochemistry studies. Compared with MI group, SG treatment dose-dependently improved cardiac hemodynamic function, attenuated infarct size, increased microvessel density, and increased the expression of PECAM-1/CD31 and VEGF. Conclusions. SG dose-dependently improved cardiac hemodynamic function and attenuated infarct size by promoting angiogenesis through upregulating PECAM-1/CD31 and VEGF expression.
基金：
National Natural Science Foundation of China [81403341]; Guangdong Provincial Science and Technology Plan [2016A020226011, 2014A020221045]; Guangzhou Science and Technology Plan project [201605131041587]
第一作者机构：[1]Cardiovascular Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China
通讯作者：
通讯机构：[1]Cardiovascular Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China[3]Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510080, China
推荐引用方式(GB/T 7714)：
Xu Dan-Ping,Zou De-Zhi,Qiu Hui-Liang,et al.Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM-1/CD31 and VEGF Expression[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2017,2017:doi:10.1155/2017/5261729.
APA：
Xu, Dan-Ping,Zou, De-Zhi,Qiu, Hui-Liang&Wu, Huan-Lin.(2017).Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM-1/CD31 and VEGF Expression.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017,
MLA：
Xu, Dan-Ping,et al."Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM-1/CD31 and VEGF Expression".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017.(2017)
