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Comparative effectiveness of six Chinese herb formulas for acute exacerbation of chronic obstructive pulmonary disease: protocol for systematic review and network meta-analysis

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机构: [1]EBM & Clinical Research Service Group, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China [5]Department of respiration, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Introduction Chinese medicine is commonly used to combine with pharmacotherapy for the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Six Chinese herb formulas involving Weijing decoction, Maxingshigan decoction, Yuebijiabanxia decoction, Qingqihuatan decoction, Dingchuan decoction and Sangbaipi decoction are recommended in Chinese medicine clinical guideline or textbook, to relieve patients with phlegm-heat according to Chinese syndrome differentiation. However, the comparative effectiveness among these six formulas has not been investigated in published randomised controlled trials. We plan to summarise the direct and indirect evidence for these six formulas combined with pharmacotherapy to determine the relative merits options for the management of AECOPD. Methods and analysis We will perform the comprehensive search for the randomised controlled trials to evaluate the effectiveness of six Chinese herb formulas recommended in Chinese medicine clinical guideline or textbook. The combination of pharmacotherapy includes bronchodilators, antibiotics and corticosteroids that are routinely prescribed for AECOPD. The primary outcome will be lung function, arterial blood gases and length of hospital stay. The data screening and extraction will be conducted by two different reviewers. The quality of RCT will be assessed according to the Cochrane handbook risk of bias tool. The Bayes of network meta-analysis (NMA) will be conducted with WinBUGS to compare the effectiveness of six formulas. We will also use the surface under the cumulative ranking curve (SUCRA) to obtain the comprehensive rank for these treatments. Ethics and dissemination This review does not require ethics approval and the results of NMA will be submitted to a peer-review journal.

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出版当年[2016]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2015]版:
Q1 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]EBM & Clinical Research Service Group, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
通讯作者:
通讯机构: [1]EBM & Clinical Research Service Group, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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