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Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014

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收录情况： ◇ SCIE

作者：
L. Huang[1,2] * ; X. Luo[1,2] ; J. Shao[1,3] ; H. Yan[1,2] ; Y. Qiu[4] ; P. Ke[5] ; W. Zheng[6] ; B. Xu &[7] ; W. Li[8] ; D. Sun[4] ; D. Cao[9] ; C. Chen[10] ; F. Zhuo[11] ; X. Lin[12] ; F. Tang[13] ; B. Bao[14] ; Y. Zhou[15] ; X. Zhang[16] ; H. Li[17] ; J. Li[18] ; D. Wan[19] ; L. Yang[20] ; Y. Chen[21] ; Q. Zhong[22] ; X. Gu[23] ; J. Liu[24] ; L. Huang[25] ; R. Xie[26] ; X. Li [27] ; Y. Xu[1,2] ; Z. Luo[1,2] ; M. Liao[1,2] ; H. Wang[1,2] ; L. Sun[1,2] ; H. Li[1,2] ; G. W. Lau[28] ; C. Duan[1,2] ;
机构： [1]Guangdong Provincial Key Laboratory of Malignant TumorEpigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China [2]Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China [3]Medical Research Center, Sun Yat-sen Memorial Hospital, SunYat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China [4]Laboratory Medicine Center, Nanfang Hospital, Southern MedicalUniversity, Guangzhou, Guangdong 510515, People’s Republic ofChina [5]Department of Clinical Laboratory, Guangdong Provincial Hospitalof Chinese Medicine, Guangzhou, Guangdong 510120, People’sRepublic of China [6]Department of Clinical Laboratory, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou, Guangdong 510080, People’s Republic of China [7]Department of Laboratory Medicine, Guangzhou First MunicipalPeople’s Hospital, Affiliated Hospital of Guangzhou MedicalCollege, Guangzhou, Guangdong 510180, People’s Republic ofChina [8]Department of Clinical Laboratory, The First People’s Hospital ofFoshan, Foshan, Guangdong 528000, People’s Republic of China [9]Department of Laboratory Medicine, Guangdong No.2 ProvincialPeople’s Hospital, Guangzhou, Guangdong 510317, People’sRepublic of China [10]Department of Clinical Laboratory, Zhanjiang Center People’sHospital, Zhanjiang, Guangdong 524037, People’s Republic ofChina [11]Luohu District Center for Disease Control and Prevention,Shenzhen, Guangdong 518020, People’s Republic of China [12]Department of Clinical Laboratory, Shantou Central Hospital,Shantou, Guangdong 515021, People’s Republic of China [13]Department of Clinical Laboratory, Zhuhai People’s Hospital,Zhuhai Hospital of Jinan University, Zhuhai, Guangdong 522000,China [14]Department of Clinical Laboratory, 12th Guangzhou People’sHospital, Guangzhou, Guangdong 510420, People’s Republic ofChina [15]Department of Clinical Laboratory, Guangzhou Xinhai Hospital,Guangzhou, Guangdong 510300, People’s Republic of China [16]Department of Laboratory Diagnosis, Sun Yat-sen UniversityAffiliated Zhongshan Hospital, Sun Yat-sen University,Zhongshan, Guangdong 528403, China [17]Department of Clinical Laboratory, Zhaoqing People’s Hospital,Zhaoqing, Guangdong 526040, China [18]Department of Clinical Laboratory, Qingyuan People’s Hospital,Qingyuan, Guangdong 511518, China [19]Department of Clinical Laboratory, Dongguan People’s Hospital,Dongguan, Guangdong 523059, China [20]Department of Clinical Laboratory, Chaozhou Central Hospital,Chaozhou, Guangdong 521021, China [21]Department of Clinical Laboratory, Maoming People’s Hospital,Maoming, Guangdong 525000, China [22]Department of Clinical Laboratory, Jieyang People’s Hospital,Jieyang, Guangdong 522000, China [23]Department of Clinical Laboratory, Heyuan People’s Hospital,Heyuan, Guangdong 517000, China [24]Department of Clinical Laboratory, Huizhou First MunicipalPeople’s Hospital, Huizhou, Guangdong 516003, China [25]Department of Clinical Laboratory, Shaoguan People’s Hospital,Shaoguan, Guangdong 512000, China [26]Department of Clinical Laboratory, Yunfu People’s Hospital,Yunfu, Guangdong 527300, China [27]Department of Clinical Laboratory, Shanwei Yihui FoundationHospital, Shanwei, Guangdong 516600, China [28]Department of Pathobiology, University of Illinois atUrbana-Champaign, Urbana, IL 61802, USA
出处：
DOI： 10.1007/s10096-015-2540-5
ISSN：

摘要：
Dengue is a rapidly spreading mosquito-borne disease caused by the dengue virus (DENV) and has emerged as a severe public health problem around the world. Guangdong, one of the southern Chinese provinces, experienced a serious outbreak of dengue in 2014, which was believed to be the worst dengue epidemic in China over the last 20 years. To better understand the epidemic, we collected the epidemiological data of the outbreak and analyzed 14,594 clinically suspected dengue patients from 25 hospitals in Guangdong. Dengue cases were then laboratory-confirmed by the detection of DENV non-structural protein 1 (NS1) antigen and/or DENV RNA. Afterwards, clinical manifestations of dengue patients were analyzed and 93 laboratory-positive serum specimens were chosen for the DENV serotyping and molecular analysis. Our data showed that the 2014 dengue outbreak in Guangdong had spread to 20 cities and more than 45 thousand people suffered from dengue fever. Of 14,594 participants, 11,387 were definitively diagnosed. Most manifested with a typical non-severe clinical course, and 1.96 % developed to severe dengue. The strains isolated successfully from the serum samples were identified as DENV-1. Genetic analyses revealed that the strains were classified into genotypes I and V of DENV-1, and the dengue epidemic of Guangdong in 2014 was caused by indigenous cases and imported cases from the neighboring Southeast Asian countries of Malaysia and Singapore. Overall, our study is informative and significant to the 2014 dengue outbreak in Guangdong and will provide crucial implications for dengue prevention and control in China and elsewhere.

基金：
Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [S2013010014007, 2014A030313070]; Guangdong Province Science & Technology Project Plan & Social Development Foundation [2010A030400006]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 微生物学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 微生物学
JCR分区：
出版当年[2014]版：
Q2 INFECTIOUS DISEASES Q2 MICROBIOLOGY
最新[2023]版：
Q2 INFECTIOUS DISEASES Q2 MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Guangdong Provincial Key Laboratory of Malignant TumorEpigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China [2]Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China
通讯作者：
通讯机构： [1]Guangdong Provincial Key Laboratory of Malignant TumorEpigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China [2]Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, Guangdong 510120, People’sRepublic of China
推荐引用方式(GB/T 7714)：
L. Huang,X. Luo,J. Shao,et al.Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014[J].EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.2016,35(2):269-277.doi:10.1007/s10096-015-2540-5.
APA：
L. Huang,X. Luo,J. Shao,H. Yan,Y. Qiu...&C. Duan.(2016).Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,35,(2)
MLA：
L. Huang,et al."Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 35..2(2016):269-277

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