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Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease

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收录情况： ◇ SCIE

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机构： [1]School of Pharmaceutical Sciences, Sun Yat-Sen University,Guangzhou 510006, China [2]International Joint Laboratory (SYSU-PolyU HK) of NovelAnti-Dementia Drugs of Guangdong, Guangzhou 510006,China [3]National and Local United Engineering Lab of Druggabilityand New Drugs Evaluation, Sun Yat-Sen University,Guangzhou 510080, China [4]The Second Affiliated Hospital of Guangzhou University ofChinese Medicine, Guangdong Provincial Key Laboratory ofClinical Research on Traditional Chinese MedicineSyndrome, Guangzhou 510120, China [5]Department of Traditional Chinese Medicine, The FirstAffiliated Hospital, Sun Yat-Sen University, Zhongshan 2Rd. 58, Guangzhou 510080, China [6]Department de Fisicoquı´mica, Facultat de Farma`cia, andInstitut de Nanocie`ncia i Nanotecnologia (IN2UB),Universitat de Barcelona, Av. Joan XXIII, 27-31,08028 Barcelona, Spain [7]Department of Applied Biology and Chemical Technology,Institute of Modern Chinese Medicine, The Hong KongPolytechnic University, Hung Hom, Hong Kong, China [8]Guangdong Province Key Laboratory of Brain Function andDisease, Zhongshan School of Medicine, Sun Yat-SenUniversity, Guangzhou 510080, China

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关键词： Xanthones Neuroprotection Oxidative stress Alzheimer's disease Multifunction

摘要：

Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named alpha-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and gamma-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced beta-amyloid (A beta) aggregation and also beta-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, alpha-Mangostin, Gartanin, Garcinone C and gamma-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical th can Trolox, and potent neuroprotective effects against glutamate-induced HT22ell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and gamma-Mangostin could be able to penetrate the blood-brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区生化与分子生物学 4 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区神经科学

JCR分区：

出版当年[2014]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 3.8 最新五年平均 2.593 出版当年[2014版] 2.333 出版当年五年平均 2.551 出版前一年[2013版] 2.472 出版后一年[2015版]

第一作者：

第一作者机构： [1]School of Pharmaceutical Sciences, Sun Yat-Sen University,Guangzhou 510006, China [2]International Joint Laboratory (SYSU-PolyU HK) of NovelAnti-Dementia Drugs of Guangdong, Guangzhou 510006,China [3]National and Local United Engineering Lab of Druggabilityand New Drugs Evaluation, Sun Yat-Sen University,Guangzhou 510080, China

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通讯作者：

通讯机构： [1]School of Pharmaceutical Sciences, Sun Yat-Sen University,Guangzhou 510006, China [2]International Joint Laboratory (SYSU-PolyU HK) of NovelAnti-Dementia Drugs of Guangdong, Guangzhou 510006,China [3]National and Local United Engineering Lab of Druggabilityand New Drugs Evaluation, Sun Yat-Sen University,Guangzhou 510080, China

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Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease

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