机构：[1]School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[2]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院[3]The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院
The Chongcao-Shencha (CCSC), a Chinese herbal compound formula, has been widely used as food material and medicine for enhancing physical strength. The present study investigated the possible effect of CCSC in alleviating the liver and kidney injury in D-galactose- (D-gal-) treated mice and the underlying mechanism. Mice were given a subcutaneous injection of D-gal (200 mg/kg) and orally administered CCSC (200, 400, and 800 mg/kg) daily for 8 weeks. Results indicated that CCSC increased the depressed body weight and organ index induced by D-gal, ameliorated the histological deterioration, and decreased the levels of ALT, AST, BUN, and CRE as compared with D-gal group. Furthermore, CCSC not only elevated the activities of antioxidant enzymes SOD, CAT, and GPx but also upregulated the mRNA expression of SOD1, CAT, and GPx1, while decreasing the MDA level in D-gal-treated mice. Results of western blotting analysis showed that CCSC significantly inhibited the upregulation of expression of nuclear factor kappa B (NF-kappa B) p65, p-p65, p-I kappa B alpha, COX2, and iNOS and inhibited the downregulation of I kappa B alpha protein expression caused by D-gal. This study demonstrated that CCSC could attenuate the liver and kidney injury in D-gal-treated mice, and the mechanism might be associated with attenuating oxidative stress and inflammatory response.
基金：
Guangdong
Natural Science Foundation (2015A030310217), Science
and Technology Planning Project of Guangzhou (no.
201300000145), Ph.D. Programs Foundation of Ministry of
Education of China (no. 20134425110009), Science and Technology
Innovation Project of Guangdong Provincial Department
of Education (no. 2013KJCX0045), Development and
Industrialization Planning Project of Guangdong Province
(nos. 2013B090600007 and 2013B090600026), Science and
Technology Planning Project of Guangdong Province (nos.
2014A020221042 and 2013A022100001), Dongguan International
Scientific and Technological Cooperation Project
(no. 201350810200151), and College Students’ Innovative
Entrepreneurial Training of Guangdong Province (no.
201410572067).
第一作者机构：[1]School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Cailan,Mo Zhizhun,Xie Jianhui,et al.Chongcao-Shencha Attenuates Liver and Kidney Injury through Attenuating Oxidative Stress and Inflammatory Response in D-Galactose-Treated Mice[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2016,2016:doi:10.1155/2016/3878740.
APA：
Li, Cailan,Mo, Zhizhun,Xie, Jianhui,Xu, Lieqiang,Tan, Lihua...&Su, Zuqing.(2016).Chongcao-Shencha Attenuates Liver and Kidney Injury through Attenuating Oxidative Stress and Inflammatory Response in D-Galactose-Treated Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,
MLA：
Li, Cailan,et al."Chongcao-Shencha Attenuates Liver and Kidney Injury through Attenuating Oxidative Stress and Inflammatory Response in D-Galactose-Treated Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2016.(2016)
