机构：[a]Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China深圳市中医院深圳医学信息中心[b]Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China深圳市中医院深圳医学信息中心[c]Guangdong Provincial Acadamy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China广东省中医院
Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of numerous human diseases. However, the reparative ability of BMSCs is limited by their poor migration. Polydatin, widely used in traditional Chinese remedies, has proven to exert protective effects to BMSCs. However, little is known about its role in BMSCs migration. In this study, we studied the effects of polydatin on rat BMSCs migration using the scratch wound healing and transwell migration assays. Our results showed polydatin could promote BMSCs migration. Further experiments showed activation of ERK 1/2, but not JNK, was required for polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs migration via the ERK 1/2 signaling pathways. Taken together, our results indicate that polydatin might be beneficial for stem cell replacement therapy by improving BMSCs migration. (C) 2016 Elsevier Masson SAS. All rights reserved.
基金：
This study was supported by grants from the project of the National Natural Science Foundation of China (Nos. 81473697,81573996, and 81302994).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2014]版：
Q3PHARMACOLOGY & PHARMACYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[a]Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China[b]Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Baiyun District, Guangzhou, Guangdong 510405, China[b]Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China[c]Guangdong Provincial Acadamy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China[*1]Key Laboratory of Orthopaedics & Traumatology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
推荐引用方式(GB/T 7714)：
ZhenQiu Chen,QiuShi Wei,GuoJu Hong,et al.Polydatin induces bone marrow stromal cells migration by activation of ERK1/2[J].BIOMEDICINE & PHARMACOTHERAPY.2016,82:49-53.doi:10.1016/j.biopha.2016.04.059.
APA：
ZhenQiu Chen,QiuShi Wei,GuoJu Hong,Da Chen,Jiang Liang...&Mei Hui Chen.(2016).Polydatin induces bone marrow stromal cells migration by activation of ERK1/2.BIOMEDICINE & PHARMACOTHERAPY,82,
MLA：
ZhenQiu Chen,et al."Polydatin induces bone marrow stromal cells migration by activation of ERK1/2".BIOMEDICINE & PHARMACOTHERAPY 82.(2016):49-53
