Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials
机构:[1]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, China广东省中医院[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, China[3]School of Information Technology, York University, Canada
This study aimed to evaluate the efficacy and safety of Chinese herbal medicine auxiliary therapy (CHMAT) in treating childhood cough variant asthma (CVA). A systematic literature review was conducted on RCTs that compared CHMAT, i.e., Chinese herbal medicine (CHM) plus pharmacotherapy (PT), versus the same PT alone in the treatment of CVA. All included trials were assessed for quality and risk bias and analyzed according to the criteria of the Cochrane Handbook based on the Review Manager 5.3 software program. Twenty studies were identified and the CHMAT group had a positive effect on the total effective rate and a lower recurrence rate compared with the control group. CHMAT may have positive effects on CVA, leading to better improvement in disorders of cough and asthma and less adverse effects. However, the methodology and reporting quality of current studies are generally low. Further studies should include larger sample sizes with a strict design to confirm these findings.
基金:
National Natural Science Foundation of China [61105053]; Cultivation Project for Excellent Doctoral Dissertation of Guangdong Province [A1-AFD015141Z10504]; Characteristic Key Discipline Construction Fund of Chinese Internal Medicine of Guangzhou University of Chinese Medicine; South China Chinese Medicine Collaborative Innovation Center [A1-AFD01514A05]
第一作者机构:[1]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Song Ping,Zeng Lingfeng,Liang Zhaohui,et al.Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials[J].INTERNAL MEDICINE.2016,55(16):2135-2143.doi:10.2169/internalmedicine.55.5546.
APA:
Song, Ping,Zeng, Lingfeng,Liang, Zhaohui,Wang, Qi&Ou, Aihua.(2016).Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials.INTERNAL MEDICINE,55,(16)
MLA:
Song, Ping,et al."Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials".INTERNAL MEDICINE 55..16(2016):2135-2143