The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder
机构：[1]Pharmaceutical Department of The First Affiliated Hospital ofGuangdong Pharmaceutical University, Clinical PharmacyDepartment of Guangdong Pharmaceutical University,Guangzhou 510080, People’s Republic China[2]Department of Neurosurgery, Beijing Tiantan Hospital, CapitalMedical University, Beijing 100050, People’s Republic China首都医科大学附属天坛医院[3]Department of ICU, Shunde TCM Hospital Affiliated to GuangzhouUniversity of Traditional Chinese Medicine, Foshan 528333,People’s Republic China[4]Department of Endocrinology, Guangdong Provincial Hospital ofChinese Medicine, Guangzhou 510120, People’s Republic China[5]Pharmacy Department of General Hospital of Chinese People’sArmed Police Forces, Beijing 100039, People’s Republic China
Post-traumatic stress disorder (PTSD) is a severe psychiatric condition. The allopregnanolone biosynthesis has been implicated as one of the possible contributors to PTSD. Inulin-type oligosaccharides of morinda officinalis (IOMO) had been shown to be effective in the therapy of depression. However, few studies concern the anti-PTSD-like effects of IOMO. To evaluate this, the single prolonged stress (SPS) model was used in the present study. It had been shown that the behavioral deficits of SPS-treated rats were reversed by IOMO (25.0 and 50.0 mg/kg, i.p.), which reversed the increased freezing time in contextual fear paradigm (CFP) and the decreased time and entries in open arms in the elevated plus maze (EPM) test without affecting the locomotor activity in the open field (OF) test. In addition, the decreased allopregnanolone in the prefrontal cortex, hippocampus, and amygdala was reversed by IOMO (25.0 and 50.0 mg/kg, i.p.), respectively. In summary, the present study indicated that the IOMO exert anti-PTSD-like behaviors, which maybe associated with the brain allopregnanolone biosynthesis.
基金：
Guangdong Natural Science Foundation of ChinaNational Natural Science Foundation of Guangdong Province [2014A030310103]
第一作者机构：[1]Pharmaceutical Department of The First Affiliated Hospital ofGuangdong Pharmaceutical University, Clinical PharmacyDepartment of Guangdong Pharmaceutical University,Guangzhou 510080, People’s Republic China
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推荐引用方式(GB/T 7714)：
Qiu Zhi-Kun,Liu Chun-Hui,Gao Zhuo-Wei,et al.The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder[J].METABOLIC BRAIN DISEASE.2016,31(5):1143-1149.doi:10.1007/s11011-016-9853-7.
APA：
Qiu, Zhi-Kun,Liu, Chun-Hui,Gao, Zhuo-Wei,He, Jia-Li,Liu, Xu...&Chen, Ji-Sheng.(2016).The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder.METABOLIC BRAIN DISEASE,31,(5)
MLA：
Qiu, Zhi-Kun,et al."The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder".METABOLIC BRAIN DISEASE 31..5(2016):1143-1149
