机构：[1]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixian’ge Street, Xicheng, Beijing, China 100053.[2]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, 16 Nanxiaojie Dongzhimennei, Dongcheng, Beijing, China 100700.[3]West China Hospital of Sichuan University, Chengdu, Sichuan, 37 Guoxuexiang, Wuhou, Chengdu, Sichuan, China 610041.四川大学华西医院[4]Yueyang Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Hongkou, Shanghai, China 200437.[5]The Third Affiliated Hospital of Zhejiang Chinese Medical University, 219 Moganshan Road, Gongshu, Hangzhou, Zhejiang, China 310005.[6]Guangdong Province Hospital of Traditional Chinese Medicine, 111 Dade Road, Yuexiu, Guangzhou, Guangdong, China 510120.大德路总院广东省中医院[7]The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 314, Anshan West Road, Nankai, Tianjin, China 300000.[8]Jiangsu Province Hospital of Traditional Chinese Medicine, 155 Hanzhong Road, Qinhuai, Nanjing, Jiangsu, China 210029.江苏省人民医院[9]Beijing Traditional Chinese Medicine Hospital of Capital Medical University, 23 Meishuguan Houjie, Dongcheng, Beijing, China 100010.[10]Heilongjiang Province Academy of Chinese Medical Science, 33 Xidazhi Street, Nangang, Ha’erbin, Heilongjiang, China 150080.[11]The First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, Anhui, China 230031.[12]Wuhan Integrated Traditional Chinese Medicine and Western Medical Hospital, 215 Zhongshan Avenue, Qiaokou, Wuhan, Hubei, China 430022.[13]Nanjing University of Chinese Medicine, 282 Hanzhong Road, Gulou, Nanjing, Jiangsu, China 210029.[14]Dongzhimen Hospital of Beijing University of Chinese Medicine, 5 Haiyuncang, Dongcheng, Beijing, China 100700.[15]Huguosi Hospital of Chinese Medicine of Beijing University of Chinese Medicine, 83 Mianhua Hutong, Xicheng, Beijing, China 100035.[16]Hubei Provincial Hospital of Traditional Chinese Medicine, 4 Huayuanshan Street, Wuhan, Hubei, China 430061.[17]Daemen College, Physical Therapy Wound Care Clinic, 4380 Main Street, Amherst, NY 14226.[18]China Academy of Chinese Medical Sciences, 16 Nanxiaojie Dongzhimennei, Dongcheng, Beijing, China 100700.
Background: Acupuncture has been used for chronic constipation, but evidence for its effectiveness remains scarce. Objective: To determine the efficacy of electroacupuncture (EA) for chronic severe functional constipation (CSFC). Design: Randomized, parallel, sham-controlled trial. (Clinical Trials. gov: NCT01726504) Setting: 15 hospitals in China. Participants: Patients with CSFC and no serious underlying pathologic cause for constipation. Intervention: 28 sessions of EA at traditional acupoints or sham EA (SA) at nonacupoints over 8 weeks. Measurements: The primary outcome was the change from baseline in mean weekly complete spontaneous bowel movements (CSBMs) during weeks 1 to 8. Participants were followed until week 20. Results: 1075 patients (536 and 539 in the EA and SA groups, respectively) were enrolled. The increase from baseline in mean weekly CSBMs during weeks 1 to 8 was 1.76 (95% CI, 1.61 to 1.89) in the EA group and 0.87 (CI, 0.73 to 0.97) in the SA group (between-group difference, 0.90 [CI, 0.74 to 1.10]; P < 0.001). The change from baseline in mean weekly CSBMs during weeks 9 to 20 was 1.96 (CI, 1.78 to 2.11) in the EA group and 0.89 (CI, 0.69 to 0.95) in the SA group (between-group difference, 1.09 [CI, 0.94 to 1.31]; P < 0.001). The proportion of patients having 3 or more mean weekly CSBMs in the EA group was 31.3% and 37.7% over the treatment and follow-up periods, respectively, compared with 12.1% and 14.1% in the SA group (P < 0.001). Acupuncture-related adverse events during treatment were infrequent in both groups, and all were mild or transient. Limitations: Longer-term follow-up was not assessed. Acupuncturists could not be blinded. Conclusion: Eight weeks of EA increases CSBMs and is safe for the treatment of CSFC. Additional study is warranted to evaluate a longer-term treatment and follow-up.
基金：
Grant Support: By the Ministry of Science and Technology of
the People's Republic of China through the Twelfth Five-Year
National Science and Technology Pillar Program (grant
2012BAI24B01).
第一作者机构：[1]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixian’ge Street, Xicheng, Beijing, China 100053.
通讯作者：
通讯机构：[18]China Academy of Chinese Medical Sciences, 16 Nanxiaojie Dongzhimennei, Dongcheng, Beijing, China 100700.[*1]China Academy of Chinese Medical Sciences, 16 Nanxiaojie Dongzhimennei, Dongcheng, Beijing, China 100700
推荐引用方式(GB/T 7714)：
Zhishun Liu,Shiyan Yan,Jiani Wu,et al.Acupuncture for Chronic Severe Functional Constipation A Randomized Trial[J].ANNALS OF INTERNAL MEDICINE.2016,165(11):761-+.doi:10.7326/M15-3118.
APA：
Zhishun Liu,Shiyan Yan,Jiani Wu,Liyun He,Ning Li...&Baoyan Liu.(2016).Acupuncture for Chronic Severe Functional Constipation A Randomized Trial.ANNALS OF INTERNAL MEDICINE,165,(11)
MLA：
Zhishun Liu,et al."Acupuncture for Chronic Severe Functional Constipation A Randomized Trial".ANNALS OF INTERNAL MEDICINE 165..11(2016):761-+
医学