机构：[1]Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China[2]Department of Pathology, Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, China[3]Department of Blood Transfusion, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, China大德路总院输血科输血科广东省中医院[4]Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA[5]Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, China
To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin's lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.
基金：
Grant sponsor: Specialized Research Fund for
the Doctoral Program of Higher Education; Grant number:
20133706110001; Grant sponsor: Natural Science Foundation of
Shandong Province; Grant number: ZR2011CM016. Grant sponsor:
Science and Technology of Qingdao City, China; Grant number:
13-1-3-50-jch.
第一作者机构：[1]Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China
通讯作者：
推荐引用方式(GB/T 7714)：
Han Lu,Sun Lingling,Zhao Zhenzhen,et al.Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma[J].ARCHIVES OF VIROLOGY.2015,160(2):441-445.doi:10.1007/s00705-014-2279-9.
APA：
Han, Lu,Sun, Lingling,Zhao, Zhenzhen,Chao, Yan,Sun, Zhifu...&Luo, Bing.(2015).Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma.ARCHIVES OF VIROLOGY,160,(2)
MLA：
Han, Lu,et al."Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma".ARCHIVES OF VIROLOGY 160..2(2015):441-445
