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Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways

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收录情况： ◇ SCIE

作者：
Zhou, Chi[1] * ; Liu, Wengang[2] * ; He, Wei[1] ; Wang, Haibin[1,*1] ; Chen, Qunqun[1] ; Song, Houpan[3,*2] ;
机构： [1]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [2]The 2nd Traditional Chinese Medicine Hospital of Guangdong Province, Guangdong Province, China [3]Institute of TCM Diagnostic, Hunan University of Chinese Medicine, Changsha, Hunan 410007, China
出处：
DOI： 10.1016/j.intimp.2015.01.010
ISSN：

关键词： Saikosaponin a Osteoclast RANKL NF-kappa B MAPK

摘要：
Inflammatory cytokines play an important role in osteoclastogenesis. Saikosaponin a (SSa) possesses anti-inflammatory activity. However, the role of SSa in osteoporosis is still unclear. Therefore, the objective of this study was to investigate the effects of SSa on receptor activator of the nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and signaling pathway by in vitro assay. In mouse bone marrow monocytes (BMMs), SSa suppressed RANKL plus macrophage colony-stimulating factor (M-CSF)-induced osteodast differentiation in a dose-dependent manner. Moreover, SSa decreased osteoclastogenesis-related marker proteins expression, including NFATcl, c-fos and cathepsin K At molecular levels, SSa inhibited RANKL-induced I kappa B alpha phosphotylation, p65 phosphorylation and NF-kappa B luciferase activity in RAW264.7 cells. And SSa also suppressed RANKL-induced p-38, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) phosphorylation. Taken together, these findings suggest that SSa suppresses osteoclastogenesis through inhibiting RANKL-induced p-38, ERK, JNK and NF-kappa B activation. SSa is a novel agent in the treatment of osteodast-related diseases, such as osteoporosis. (C) 2015 Elsevier B.V. All rights reserved.

基金：
Natural Science Foundation of China (grant number: 81373665) and Industrial Technology Research and Development Fund of Guangdong Province (grant number: 2013B021800226).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 医学
小类 | 3 区 药学 4 区 免疫学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
JCR分区：
出版当年[2013]版：
Q2 PHARMACOLOGY & PHARMACY Q3 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
共同第一作者：
通讯作者：
通讯机构： [1]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [3]Institute of TCM Diagnostic, Hunan University of Chinese Medicine, Changsha, Hunan 410007, China [*1]The first Affiliated Hospital of Guangzhou University of Chinese Medicine, 16 Airport Road, Baiyun District, Guangzhou 510405, China.
推荐引用方式(GB/T 7714)：
Zhou Chi,Liu Wengang,He Wei,et al.Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2015,25(1):49-54.doi:10.1016/j.intimp.2015.01.010.
APA：
Zhou, Chi,Liu, Wengang,He, Wei,Wang, Haibin,Chen, Qunqun&Song, Houpan.(2015).Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways.INTERNATIONAL IMMUNOPHARMACOLOGY,25,(1)
MLA：
Zhou, Chi,et al."Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways".INTERNATIONAL IMMUNOPHARMACOLOGY 25..1(2015):49-54

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