机构：[1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China,广东省中医院[2]Department of Clinical Laboratory Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China,[3]Department of Clinical Laboratory Medicine, Zhongshan Hospital of Fudan University, Shanghai, China,[4]Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China,[5]National Center for Clinical Laboratories, Beijing Hospital, Beijing, China,[6]Department of Laboratory medicine, West China Hospital, Sichuan University, Sichuan, China,四川大学华西医院[7]Department of Clinical Laboratory Medicine, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China
Background Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults. Methods A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples. Results Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles. Conclusion We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.
基金：
National Key
Technologies R&D Program of China
(2012BAI37B01).
第一作者机构：[1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Xinzhong,Zhao Min,Pan Baishen,et al.Complete Blood Count Reference Intervals for Healthy Han Chinese Adults[J].PLOS ONE.2015,10(3):doi:10.1371/journal.pone.0119669.
APA：
Wu, Xinzhong,Zhao, Min,Pan, Baishen,Zhang, Jie,Peng, Mingting...&Shang, Hong.(2015).Complete Blood Count Reference Intervals for Healthy Han Chinese Adults.PLOS ONE,10,(3)
MLA：
Wu, Xinzhong,et al."Complete Blood Count Reference Intervals for Healthy Han Chinese Adults".PLOS ONE 10..3(2015)
