机构:[1]Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou 510120, China中山大学附属第二医院[2]Department of Breast Surgery, Guangdong Hospital of Traditional Chinese Medicine, Traditional Chinese Medicine University of Guangzhou, 111 Dade Road, Guangzhou 510120, China大德路总院乳腺科大德路总院乳腺科广东省中医院大德路总院乳腺科门诊乳腺科大德路总院[3]Department ofHepatic Surgery, TheThird Affiliated Hospital, Sun Yat-senUniversity, 600 Tianhe Road, Guangzhou 510630, China中山大学附属第三医院[4]Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshaner Road, Guangzhou 510080, China
Title. Chemotherapy-induced myelosuppression lowers the quality of life in breast cancer patients and causes many complications. Traditional Chinese Medicine (TCM) is a widely used complementary and alternative medicine therapies. Objective. To study whether TCM can reduce the incidence of chemotherapy-induced leukopenia, neutropenia, and febrile neutropenia (FN) in breast cancer patients. Methods. The data were analyzed retrospectively between patients who received TCM treatment (group 1, n = 453) and patients who did not receive TCM treatment (group 2, n = 359). Significant risk factors associated with the occurrence of chemotherapy-induced leukopenia, neutropenia, and FN were identified using multivariate analysis. Propensity score-matched patients were analyzed to adjust for any baseline differences. Results. Group 1 patients had a significantly lower rate of chemotherapy-induced severe leukopenia, neutropenia, and FN, compared with group 2 (43% versus 71%, p < 0.0001, 72% versus 78%, p = 0.005, 6% versus 24%, p < 0.0001, resp.). Multivariate analysis revealed that chemotherapy regimens containing anthracyclines combined with paclitaxel or docetaxel were the most significant predictor. Subgroup analysis indicated that TCM treatment showed benefit in relieving chemotherapy-induced leukopenia and FN in most chemotherapy regimens. Conclusions. TCM treatment could lower the risk of severe chemotherapy-induced leukopenia, neutropenia, and FN in breast cancer patients.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81172524, 81372817]
第一作者机构:[1]Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou 510120, China[2]Department of Breast Surgery, Guangdong Hospital of Traditional Chinese Medicine, Traditional Chinese Medicine University of Guangzhou, 111 Dade Road, Guangzhou 510120, China
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推荐引用方式(GB/T 7714):
Tian Huan,Qin Wei,Wu Wenjing,et al.Effects of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2015,2015:doi:10.1155/2015/736197.
APA:
Tian, Huan,Qin, Wei,Wu, Wenjing,Guo, Pi,Lu, Yong...&Su, Fengxi.(2015).Effects of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2015,
MLA:
Tian, Huan,et al."Effects of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015.(2015)