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MTA1 Overexpression Induces Cisplatin Resistance Innasopharyngeal Carcinoma by Promoting Cancer Stem Cells Properties

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收录情况： ◇ SCIE

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机构： [1]Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University [2]Cancer Center of Guangzhou Medical University (CCGMU), Guangzhou, China [3]Department of Otolaryngology, General Hospital of Guangzhou Command, Guangzhou, China, [4]Cancer Institute of Southern Medical University, Guangzhou, China, [5]Department of stomatology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, [6]Department of Radiotherapy, Nanfang Hospital of Southern Medical University, Guangzhou, China, [7]Cancer Center of Affiliated Hospital of Guangdong Medical College, Zhanjiang, China, [8]Department of Cardiology, 458th Hospital of People’s Liberation Army, Guangzhou, China

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关键词： cancer stem cell cisplatin-resistance MTA1 nasopharyngeal carcinoma

摘要：

Themetastasis-associated gene 1 (MTA1) oncogene hasbeen suggested to be involved in the regulation of cancer progression. However, there is still no direct evidence that MTA1 regulates cisplatin (CDDP) resistance, as well as cancer stem cell properties. In this study, we found that MTA1 was enriched in CNE1/CDDP cells. Knock down of MTA1 in CNE1/CDDP cells reversed CSCs properties and CDDP resistance. However, ectopic expression of MTA1 in CNE1 cells induced CSCs phenotypes and CDDP insensitivity. Interestingly, ectopic overexpression of MTA1-induced CSCs properties and CDDP resistance were reversed in CNE1 cells after inhibition of PI3K/Akt by LY294002. In addition, MTA1 expression and Akt activity in CNE1/CDDP cells was much higher than that in CNE1 cells. These results suggested that MTA1 may play a critical role in promoting CDDP resistance in NPC cells by regulatingcancer stem cell properties via thePI3K/Akt signaling pathway. Our findings suggested that MTA1 may be a potential target for overcoming CDDP resistance in NPC therapy.

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出版当年[2013]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 3 区细胞生物学

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出版当年[2012]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 2.21 出版当年[2012版] 2.077 出版当年五年平均 2.178 出版前一年[2011版] 2.242 出版后一年[2013版]

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第一作者机构： [2]Cancer Center of Guangzhou Medical University (CCGMU), Guangzhou, China

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