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Oral Chinese Herbal Medicine Combined with Pharmacotherapy for Stable COPD: A Systematic Review of Effect on BODE Index and Six Minute Walk Test

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机构: [1]Evidence-Based Medicine & Clinical Research Service Group, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China [2]Guangdong ProvincialHospital of Chinese Medicine, Guangzhou, China [3]Traditional & Complementary Medicine Research Program, Health Innovations Research Institute, School of HealthSciences, RMIT University, Melbourne, Australia [4]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China [5]Department of Respiratory Medicine,Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province, China
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This systematic review evaluated the effects of Chinese herbal medicine (CHM) plus routine pharmacotherapy (RP) on the objective outcome measures BODE index, 6-minute walk test (6MWT), and 6-minute walk distance (6MWD) in individuals with stable chronic obstructive pulmonary disease (COPD). Searches were conducted of six English and Chinese databases (PubMed, EMBASE, CENTRAL, CINAHL, CNKI and CQVIP) from their inceptions until 18th November 2013 for randomized controlled trials involving oral administration of CHM plus RP compared to the same RP, with BODE Index and/or 6MWT/D as outcomes. Twenty-five studies were identified. BODE Index was used in nine studies and 6MWT/D was used in 22 studies. Methodological quality was assessed using the Cochrane Risk of Bias tool. Weaknesses were identified in most studies. Six studies were judged as 'low' risk of bias for randomisation sequence generation. Twenty-two studies involving 1,834 participants were included in the meta-analyses. The main meta-analysis results showed relative benefits for BODE Index in nine studies (mean difference [MD] -0.71, 95% confidence interval [CI] -0.94, -0.47) and 6MWT/D in 17 studies (MD 54.61 meters, 95% CI 33.30, 75.92) in favour of the CHM plus RP groups. The principal plants used were Astragalus membranaceus, Panax ginseng and Cordyceps sinensis. A. membranaceus was used in combination with other herbs in 18 formulae in 16 studies. Detailed sub-group and sensitivity analyses were conducted. Clinically meaningful benefits for BODE Index and 6MWT were found in multiple studies. These therapeutic effects were promising but need to be interpreted with caution due to variations in the CHMs and RPs used and methodological weakness in the studies. These issues should be addressed in future trials.

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基金编号: GPACMS GPHCM

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出版当年[2013]版:
大类 | 2 区 生物
小类 | 2 区 综合性期刊
最新[2025]版:
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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出版当年[2012]版:
Q1 MULTIDISCIPLINARY SCIENCES
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]Evidence-Based Medicine & Clinical Research Service Group, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China [2]Guangdong ProvincialHospital of Chinese Medicine, Guangzhou, China
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