机构：[1]Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China[2]College of Information Science & Technology, Hainan University, Haikou 570228, P. R. China[3]Guangdong Provincial Academy of Chinese Medical Sciences (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), 55 Neihuanxi Road, Guangzhou 510006, P. R. China广东省中医院
Two new cycloartane triterpenoids, (23R)-21,23:23,27-diepoxycycloarta-1,24-diene-3,27-dione (1) and (3 alpha)-(alpha-L-arabinopyranosyloxy)-1 alpha-hydroxy-23-oxocycloartan-28-oic acid (2), together with six known pentacyclic triterpenoids, 3-8, and five known C-29 steroids, 9-13, were isolated from Kleinhovia hospita. The structures of these compounds were determined by analysis of their spectroscopic data. Moreover, the absolute configuration of 1 was confirmed by quantum-chemical TDDFT calculation of its ECD spectrum. All compounds were evaluated for their cytotoxic activities against human colon carcinoma (HCT116) and gastric carcinoma (SGC7901) cell lines, and compounds 6, 7, 8, 11, and 12 exhibited antiproliferative activities with IC50 values ranging from 23.0 to 91.8 mu m.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21372198, 81202398]; Scientific Research Fund of Zhejiang Provincial Education Department [Y201122364]
第一作者机构：[1]Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Mo Jian-Xia,Bai Yang,Liu Bo,et al.Two New Cycloartane Triterpenoids from Kleinhovia hospita[J].HELVETICA CHIMICA ACTA.2014,97(6):887-894.doi:10.1002/hlca.201300331.
APA：
Mo, Jian-Xia,Bai, Yang,Liu, Bo,Zhou, Chang-Xin,Zou, Li&Gan, Li-She.(2014).Two New Cycloartane Triterpenoids from Kleinhovia hospita.HELVETICA CHIMICA ACTA,97,(6)
MLA：
Mo, Jian-Xia,et al."Two New Cycloartane Triterpenoids from Kleinhovia hospita".HELVETICA CHIMICA ACTA 97..6(2014):887-894
