机构：[1]Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin,Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China[2]State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory ofCancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing 211166, China[3]Department of GynecologicOncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China[4]Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai200032, China[5]Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China[6]College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China[7]State Key Laboratory of Oncology in SouthernChina, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China[8]Department of Obstetrics and Gynecology, Tongji Hospital, TongjiMedical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China华中科技大学同济医学院附属同济医院[9]Department of Gynecology, Jiangsu Province Hospital ofTCM, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China江苏省人民医院[10]Department of Gynecology and Obstetrics, Tianjin Medical UniversityGeneral Hospital, Tianjin 300052, China[11]Department of Gynecologic Surgery, Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu210009, China[12]Department of Tissue Bank, Nantong Tumor Hospital, Nantong, Jiangsu 226361, China[13]Department of Pathology, The University of TexasMD Anderson Cancer Center, Houston, Texas 77030, USA[14]Department of Urology, Tianjin Medical University Cancer Institute and Hospital, Tianjin300060, China[15]Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P-meta<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P-meta = 1.88 x 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P-meta = 2.62 x 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P-meta = 1.14 x 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P-meta = 8.57 x 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.
基金：
Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) in ChinaProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1076]; National Key Scientific and Technological Project [2011ZX09307-001-04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81320108022, 81072363]; Tianjin Science and Technology Committee Foundation [09ZCZDSF04700]; National High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2012AA02A207]; China's Thousand Talents Program recruitment at Fudan University; Tianjin Cancer Institute and Hospital; U.S. National Foundation for Cancer Research
第一作者机构：[1]Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin,Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
共同第一作者：
通讯作者：
通讯机构：[4]Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai200032, China[15]Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
推荐引用方式(GB/T 7714)：
Kexin Chen,Hongxia Ma,Lian Li,et al.Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women[J].NATURE COMMUNICATIONS.2014,5:doi:10.1038/ncomms5682.
APA：
Kexin Chen,Hongxia Ma,Lian Li,Rongyu Zang,ChengWang...&Qingyi Wei.(2014).Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.NATURE COMMUNICATIONS,5,
MLA：
Kexin Chen,et al."Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women".NATURE COMMUNICATIONS 5.(2014)
综合性期刊